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SPI1 Gene - PU.1

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-spi1

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Metadata

slug	genes-spi1
entity_type	gene
kg_node_id	SPI1

Linked Artifacts (69)

mentions🧫scRNA-seq analysis of human atherosclerotic plaques80%

mentions🧫Validation of hub genes in ox-LDL treated RAW264.7 macrophag80%

mentions🧫Gene expression validation in apoE-/- mice80%

mentions🧫ox-LDL treatment of RAW264.7 macrophages80%

mentions🧫Validation of hub genes in apoE-/- atherosclerotic mice80%

related🧫scRNA-seq analysis of human atherosclerotic plaques72%

related🧫Validation of hub genes in ox-LDL treated RAW264.7 macrophag72%

related🧫Gene expression validation in apoE-/- mice72%

related🧫ox-LDL treatment of RAW264.7 macrophages72%

related🧫Validation of hub genes in apoE-/- atherosclerotic mice72%

mentions📓TREM2-Dependent Microglial Senescence Transition -- Computat70%

mentions🧪APOE Isoform Conversion Therapy70%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

see_also📓TREM2-Dependent Microglial Senescence Transition -- Computat70%

related🧪APOE Isoform Conversion Therapy63%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%

see_also📖TBP - TATA-Box Binding Protein60%

see_also📖Alzheimer Indonesia60%

see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%

see_also📖ABI3 Gene60%

see_also📖ACE Gene60%

see_also📖adam1760%

see_also📖FLNA Gene60%

see_also📖STXBP2 — Syntaxin Binding Protein 260%

see_also📖SIGLEC1 Gene60%

see_also📖Accelerating Medicines Partnership for Alzheimer's Dise60%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Complement C1q Mimetic Decoy Therapy50%

mentions🧪Complement C1q Subtype Switching50%

mentions🧪Complement C1QA Spatial Gradient in Cortical Layers50%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪Complement-Mediated Synaptic Pruning Dysregulation50%

mentions🧪Optogenetic Microglial Deactivation via Engineered Inhibitor50%

mentions🧪Fractalkine Axis Amplification via CX3CR1 Positive Allosteri50%

mentions🧪Astrocyte-Mediated Neuronal Epigenetic Rescue50%

mentions🧪APOE-Dependent Autophagy Restoration50%

mentions🧪Microglial Purinergic Reprogramming50%

mentions🧪Purinergic P2Y12 Inverse Agonist Therapy50%

mentions🧪TREM2-Dependent Microglial Senescence Transition50%

mentions🧪CYP46A1 Overexpression Gene Therapy50%

mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%

related🔬What are the mechanisms underlying neuroinflammation resolut50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬What are the mechanisms underlying neuroinflammation resolut50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🧪APOE Isoform Conversion Therapy50%

related🧪APOE-TREM2 Interaction Modulation50%

related🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

related🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition50%

related🧪Senescent Microglia Resolution via Maresins-Senolytics Combi50%

related🧪Microglial Efferocytosis Enhancement via GPR32 Superagonists50%

related🧪Orexin-Microglia Modulation Therapy50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying mechanistic role of apoe 50%

related🔬What are the mechanisms underlying synaptic pruning by micro50%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪CYP46A1 Overexpression Gene Therapy40%

related🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th40%