🧫
Microglial Aging and Immune Memory in Neurodegeneration — Training the Brain's Macrophages
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-microgli
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.908379Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['DAM'], 'diseases': ["Alzheimer's Disease"]} |
| model_system | human |
| summary | # Microglial Aging and Immune Memory in Neurodegeneration — Training the Brain's Macrophages ## Background and Rationale The human brain's resident immune cells, microglia, represent far more than pas |
| replication_status | single_study |
| methodology_notes | **Phase 1: Human Tissue Collection and Processing (Weeks 1-4)** • Collect postmortem brain tissue from n=60 donors (20 healthy controls, 20 early-stage AD, 20 advanced AD) matched for age (65-85 years |
| primary_outcome | Validate Microglial Aging and Immune Memory in Neurodegeneration — Training the Brain's Macrophages |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.908384'} |
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