gene 2,825 words KG: ADCY3 2026-03-27
kind:genesection:genesstate:published
Contents

ADCY3 — Adenylate Cyclase 3

🧬 Gene Info
Gene SymbolADCY3
Full NameAdenylate Cyclase 3
Chromosome2p23.3
Protein TypeEnzyme
Functionis a member of the adenylate cyclase family of enzymes that catalyze the conversion of ATP to cyclic AMP (cAMP), a ubiquitous second messenger critical for cellular signaling.
Primary Expressionolfactory sensory neurons where it plays a critical role in odor detection and signal transduction
Molecular Weight140 kDa
Amino Acids244 aa
UniProt ID[O60236](https://www.uniprot.org/uniprot/O60236)
Ensembl IDENSG00000138031
OMIM600019
GeneCardsADCY3
Human Protein AtlasADCY3
Associated Diseasesobesity, Alzheimer's Disease
InteractionsHDAC6, SHH, GFRAL, GDNF, HEDGEHOG
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Adenosine-Astrocyte Metabolic Reset
Score: 0.56
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Microbial Inflammasome Priming Prevention
Score: 0.58
Smartphone-Detected Motor Variability Correction
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (5)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (7)

Hedgehog Signaling in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
SHH — Sonic Hedgehog
gene · KG edge: activates
GFRAL Gene - GDNF Receptor Alpha Like
gene · KG edge: activates
HDAC6 (Redirect)
redirect · KG edge: activates

Knowledge Graph (12 edges)

ADCY3 activates HDAC6
ADCY3 activates SHH
ADCY3 activates GFRAL
ADCY3 activates GDNF
ADCY3 cleaves LAMP2A
ADCY3 activates Als
ADCY3 activates Ms
ADCY3 activates Hedgehog
ADCY3 activates HEDGEHOG
ADCY3 expressed_in neurons