concept

HEDGEHOG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEDGEHOG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

455Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	HEDGEHOG
Summary	Therapy targeting Hedgehog pathway (SHH, PTCH, SMO) to protect neurons and modulate glial function in AD, PD, ALS, FTD
Related Diseases	Ms, Als, Tumor, Amyotrophic Lateral Sclerosis, Cancer

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HEDGEHOG["HEDGEHOG"]
    HEDGEHOG -->|"interacts"| Tgf__["Tgf-Beta"]
    HEDGEHOG -->|"interacts"| Autophagy["Autophagy"]
    HEDGEHOG -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    HEDGEHOG -->|"interacts"| Notch["Notch"]
    HEDGEHOG -->|"interacts"| Epigenetic["Epigenetic"]
    HEDGEHOG -->|"interacts"| Mtor["Mtor"]
    LIF["LIF"] -->|"activates"| HEDGEHOG
    EGFR["EGFR"] -->|"activates"| HEDGEHOG
    BNIP3["BNIP3"] -->|"activates"| HEDGEHOG
    BECN1["BECN1"] -->|"activates"| HEDGEHOG
    ATG7["ATG7"] -->|"activates"| HEDGEHOG
    GLI1["GLI1"] -->|"activates"| HEDGEHOG
    BCL2["BCL2"] -->|"activates"| HEDGEHOG
    Leukemia["Leukemia"] -->|"activates"| HEDGEHOG
    Cancer["Cancer"] -->|"activates"| HEDGEHOG
    Tumor["Tumor"] -->|"activates"| HEDGEHOG

Outgoing (123)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Leukemia	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Als	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Tumor	expressed_in	disease	0.65
HDAC	therapeutic_target	gene	0.60
Notch	contributes_to	pathway	0.60
Hedgehog	contributes_to	pathway	0.60
Mtor	contributes_to	pathway	0.60
Wnt	contributes_to	pathway	0.60
Tgf-Β	contributes_to	pathway	0.60
HDAC	associated_with	gene	0.60
Hedgehog	associated_with	pathway	0.60
AND	activates	gene	0.60
LIF	activates	gene	0.60
CANCER	activates	gene	0.60
HIPPO	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
Hedgehog	activates	pathway	0.60
Wnt	activates	pathway	0.60
ATG7	activates	gene	0.60
AND	inhibits	gene	0.60
BCL2	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
BNIP3	activates	gene	0.60
GLI1	activates	gene	0.60
BECN1	activates	gene	0.60
Autophagy	activates	pathway	0.60
Hedgehog	inhibits	pathway	0.60
AND	regulates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
ALS	regulates	gene	0.60

Incoming (332)

Source	Relation	Type	Str
Cancer	therapeutic_target	disease	0.90
Als	therapeutic_target	disease	0.90
CANCER	therapeutic_target	gene	0.90
Als	regulates	disease	0.80
Tumor	therapeutic_target	disease	0.80
CANCER	regulates	gene	0.80
SHH	associated_with	gene	0.80
SMO	therapeutic_target	gene	0.80
GLI1	activates	gene	0.70
BCL2	activates	gene	0.70
Tumor	activates	disease	0.70
Inflammation	therapeutic_target	disease	0.70
Carcinoma	therapeutic_target	disease	0.70
SHH	regulates	gene	0.70
AKT	associated_with	gene	0.70
PI3K	associated_with	gene	0.70
HIPPO	regulates	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
NF-ΚB	interacts_with	gene	0.70
APOPTOSIS	regulates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
AKT	activates	gene	0.70
SHH	activates	gene	0.70
RUNX2	regulates	gene	0.70
MIRNAS	regulates	gene	0.70
APOPTOSIS	activates	gene	0.70
CANCER	implicated_in	gene	0.70
Cancer	implicated_in	disease	0.70
CANCER	associated_with	gene	0.70
Cancer	associated_with	disease	0.70
CANCER	inhibits	gene	0.70
Cancer	inhibits	disease	0.70
Autoimmune	therapeutic_target	disease	0.70
Cancer	regulates	disease	0.70
LIF	activates	gene	0.60
EGFR	activates	gene	0.60
BNIP3	activates	gene	0.60
BECN1	activates	gene	0.60
ATG7	activates	gene	0.60
Leukemia	activates	disease	0.60
Cancer	activates	disease	0.60
Ms	activates	disease	0.60
ATG	activates	gene	0.60
Carcinoma	inhibits	disease	0.60
Tumor	inhibits	disease	0.60
Ms	inhibits	disease	0.60
MTOR	regulates	gene	0.60
FOXO1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
Carcinoma	regulates	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HEDGEHOG

Understanding Entity Pages

Wiki Pages (21)

Hedgehog Signaling Modulation Therapy for Neurodegeneration

Therapeutics

blood-brain-barrier

Spinal Cord Dorsal Horn Neurons

Cellular Reprogramming Therapies for Neurodegeneration

Notch Signaling Pathway in Neurodegeneration

Neurogenesis

PTCH2 Gene

UBQLN2 — Ubiquilin 2

TBX2 — T-Box Transcription Factor 2

WNT7A Gene

GLI1 — GLI Family Zinc Finger 1

lmx1b

PAK2 Protein (p21-Activated Kinase 2)

Endolysosomal Trafficking Defects in Neurodegeneration

Adult Neurogenesis in Neurodegeneration

GPR161 — G Protein-Coupled Receptor 161

Hedgehog Signaling Pathway in Neurodegeneration

Hedgehog Signaling in Neurodegeneration

Centrosome