GFRAL

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFRAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GFRAL is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with ALS, Als, Autoimmune. Connected to 43 entities in the SciDEX knowledge graph.

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graph TD
    GFRAL["<b>GFRAL</b>"]
    BDNF_mNTS_Neurons["BDNF mNTS Neurons"]
    GFRAL -->|"activates"| BDNF_mNTS_Neurons
    GLP1R["GLP1R"]
    GFRAL -->|"co expressed with"| GLP1R
    Als{"Als"}
    GFRAL -->|"inhibits"| Als
    GFRAL -->|"activates"| Als
    Cancer{"Cancer"}
    GFRAL -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    GFRAL -->|"inhibits"| Tumor
    Ms{"Ms"}
    GFRAL -->|"activates"| Ms
    ALS{"ALS"}
    GFRAL -->|"inhibits"| ALS
    Obesity{"Obesity"}
    GFRAL -->|"therapeutic target"| Obesity
    Inflammation{"Inflammation"}
    GFRAL -->|"activates"| Inflammation
    GDNF["GDNF"]
    GFRAL -->|"inhibits"| GDNF
    BDNF["BDNF"]
    GFRAL -->|"contributes to"| BDNF
    GDF15["GDF15"]
    GDF15 -->|"binds"| GFRAL
    BDNF -->|"contributes to"| GFRAL
    GLP1R -->|"inhibits"| GFRAL
    GDNF -->|"inhibits"| GFRAL
    IL_6["IL-6"]
    IL_6 -->|"inhibits"| GFRAL
    CANCER["CANCER"]
    CANCER -->|"inhibits"| GFRAL
    HDAC6["HDAC6"]
    HDAC6 -->|"activates"| GFRAL
    GDNF -->|"regulates"| GFRAL
    SHH["SHH"]
    SHH -->|"activates"| GFRAL
    AND["AND"]
    AND -->|"therapeutic target"| GFRAL
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| GFRAL
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| GFRAL
    style GFRAL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0