gene

LAMP2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMP2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

434Connections

7Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LAMP2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 169 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LAMP2A
Protein Type	Protein
Molecular Weight	45 kDa
Amino Acids	12 aa
Exons	9
Pathways	Autophagy, Chaperone, Oxidative Stress, Proteostasis
UniProt ID	Search UniProt
GeneCards	LAMP2A
Human Protein Atlas	LAMP2A
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, amyotrophic lateral sclerosis, AND, AR, ATG
SciDEX Hypotheses	LAMP2A-Mediated Autophagy Enhancement Blocks Alpha
KG Connections	434 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LAMP2A — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    TFEB["TFEB
Transcription Factor"]
    LAMP2_gene["LAMP2 Gene"]
    LAMP2A["LAMP2A Protein
Lysosomal Membrane"]
    CMA["Chaperone-Mediated
Autophagy (CMA)"]
    ATG10["ATG10
Autophagy Gene"]
    FBXW7["FBXW7
E3 Ubiquitin Ligase"]
    
    Parkinson["Parkinson's Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    Huntington["Huntington's Disease"]
    Ataxia["Ataxia"]
    MPTP_neuro["MPTP-induced
Neurodegeneration"]
    
    mTOR["mTOR Pathway"]
    TP53["p53 Tumor
Suppressor"]
    Apoptosis["Apoptosis
Pathway"]
    Autophagy["General
Autophagy"]
    
    TFEB -->|"upregulates"| LAMP2A
    LAMP2_gene -->|"encodes"| LAMP2A
    LAMP2A -->|"regulates"| CMA
    LAMP2A -->|"activates"| CMA
    LAMP2A -->|"promotes"| FBXW7
    LAMP2A -->|"activates"| ATG10
    
    LAMP2A -->|"prevents"| MPTP_neuro
    LAMP2A -->|"inhibits"| ALS
    LAMP2A -->|"associated_with"| Parkinson
    LAMP2A -->|"associated_with"| Huntington
    LAMP2A -->|"associated_with"| Ataxia
    
    LAMP2A -->|"associated_with"| mTOR
    LAMP2A -->|"associated_with"| TP53
    LAMP2A -->|"associated_with"| Apoptosis
    CMA -->|"part_of"| Autophagy
    
    style LAMP2A fill:#006494
    style CMA fill:#1b5e20
    style FBXW7 fill:#1b5e20
    style ATG10 fill:#1b5e20
    style TFEB fill:#4a1a6b
    style TP53 fill:#4a1a6b
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style Huntington fill:#ef5350
    style MPTP_neuro fill:#ef5350
    style Ataxia fill:#5d4400

Outgoing (258)

Target	Relation	Type	Str
Chaperone-Mediated Autophagy	involved_in	process	0.95
Cytosolic Proteins	associated_with	protein	0.90
SNCA	involved_in	protein	0.85
CMA	biomarker_for	process	0.80
chaperone-mediated autophagy	regulates	process	0.70
chaperone-mediated autophagy	activates	process	0.70
MPTP-induced neurodegeneration	protects_against	process	0.70
FBXW7	activates	protein	0.70
autophagy pathway	participates_in	pathway	0.70
Parkinson's disease	activates	disease	0.70
Als	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Als	associated_with	disease	0.65
Senescence	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Parkinson	activates	disease	0.65
NRXN1	regulates	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
Autophagy	expressed_in	pathway	0.60
Tdp-43	associated_with	pathway	0.60
Sod1	associated_with	pathway	0.60
Alzheimer	associated_with	disease	0.60
cerebellum	expressed_in	brain_region	0.60
NLRP3	expressed_in	gene	0.60
NRXN1	activates	gene	0.60
NRXN1	inhibits	gene	0.60
PKM2	associated_with	gene	0.60
Actin	associated_with	protein	0.60
TH	interacts_with	gene	0.60
ACAT1	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
TREHALOSE	activates	gene	0.60
Stem Cell	associated_with	pathway	0.60
PARKINSON	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CREB	associated_with	gene	0.60

Incoming (176)

Source	Relation	Type	Str
TFEB	activates	gene	0.85
TFEB	upregulates	protein	0.85
AR7	upregulates	compound	0.85
BHB	upregulates	compound	0.80
LAMP2	encodes	gene	0.70
ATG	activates	gene	0.70
rapamycin	targets	drug	0.70
C1Q	associated_with	gene	0.60
TNF	associated_with	gene	0.60
DYRK1A	activates	gene	0.60
FADD	activates	gene	0.60
ADCY3	cleaves	gene	0.60
LAMP2	associated_with	gene	0.60
HTT	activates	gene	0.60
TDP-43	associated_with	gene	0.60
HSP70	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
ALS	activates	entity	0.60
DNA	activates	gene	0.60
HSP70	regulates	gene	0.60
AR	activates	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
GLA	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
RB1	associated_with	gene	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi	0.783	neurodegeneration	-
GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9	0.750	neurodegeneration	-
LAMP2A-Mediated Autophagy Enhancement Blocks Alpha-Synuclein	0.745	neurodegeneration	Test
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents Tors	0.733	neurodegeneration	-
Lysosomal Acidification Failure: Convergent GBA1/LAMP2A–medi	0.700	neurodegeneration	-

SNCA Aggregation Hijacks the Endosomal Sorting Complex Requi	0.690	neurodegeneration	-
LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy	0.000	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LAMP2A in their description or question text

LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy for Tau Clearance in

Score: 0.000 · proteomics · 2026-04-28

Age-related decline in chaperone-mediated autophagy (CMA) contributes to the selective accumulation of hyperphosphorylat