protein

AGERPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AGERPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

AGER, commonly known as RAGE (Receptor for Advanced Glycation End Products), is a pattern recognition receptor that plays a central role in linking metabolic stress, oxidative damage, and neuroinflammation in neurodegenerative diseases[@schmidt2000].

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🔬 Protein Info

Gene Symbol	AGERPROTEIN
Full Name	AGER/RAGE
Chromosome	6p21.3
Protein Type	Protein
Target Class	Protein
Function	is a pattern recognition receptor that plays a central role in linking metabolic stress, oxidative damage, and neuroinflammation in neurodegenerative diseases[@schmidt2000].
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade
Primary Expression	various cell types within the central nervous system, including neurons, astrocytes, microglia, and vascular endothelial cells, where it mediates resp
Druggability	Undruggable (0.23)
UniProt ID	Search UniProt
GeneCards	AGERPROTEIN
Human Protein Atlas	AGERPROTEIN
Associated Diseases	AD, ALI, als, Alzheimer's disease
Known Drugs/Compounds	CHEMBL2179074, CHEMBL2205553, CHEMBL2205552, CHEMBL2205550, CHEMBL2205549, CHEMBL2205572
Interactions	EGFR, HER2, HLA, HSPA1A, HSPA1B, NCOA4
SciDEX Target	View Target Profile
SciDEX Hypotheses	Blocking AGE-RAGE Signaling in Enteric Glia to Pre
KG Connections	144 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: AGERPROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AGER/RAGE Protein

protein · 2601 words

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Pathway Diagram

graph TD
    AGERPROTEIN["AGERPROTEIN"]
    neurodegeneration["neurodegeneration"]
    AGERPROTEIN -->|"implicated_in"| neurodegeneration
    style AGERPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AGERPROTEIN in their description or question text

No additional research found