gene

HLA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HLA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

307Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	HLA
Primary Expression	Ca1, Cortex
Pathways	Jak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response
GeneCards	HLA
Human Protein Atlas	HLA
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Cardiovascular
Interactions	CANCER, P53, IL-23, AND, GENES, HSPA1A
KG Connections	307 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HLA["HLA"] -->|"associated"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"expressed in"| Lymphoma["Lymphoma"]
    style Lymphoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| FERMT2["FERMT2"]
    style FERMT2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| RIN3["RIN3"]
    style RIN3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HLA["HLA"] -->|"associated"| ZCWPW1["ZCWPW1"]
    style ZCWPW1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| HLA["HLA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PLD3["PLD3"] -->|"associated"| HLA["HLA"]
    style PLD3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ABCA7["ABCA7"] -->|"associated"| HLA["HLA"]
    style ABCA7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SORL1["SORL1"] -->|"associated"| HLA["HLA"]
    style SORL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PICALM["PICALM"] -->|"associated"| HLA["HLA"]
    style PICALM fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style HLA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (161)

Target	Relation	Type	Str
Microglial Function	modulates	process	0.85
microglia	modulates	cell_type	0.80
microglia	expressed_in	cell_type	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
INPP5D	activates	gene	0.70
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Lymphoma	expressed_in	disease	0.65
Cardiovascular	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Tumor	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Als	biomarker_for	disease	0.65
Als	causes	disease	0.65
FERMT2	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
TERT	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
Jak-Stat	expressed_in	pathway	0.60
HSPA1B	associated_with	gene	0.60
CANCER	activates	gene	0.60
P53	interacts_with	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Monocyte	therapeutic_target	cell_type	0.60
UNC13A	associated_with	gene	0.60
GRN	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
SOD1	therapeutic_target	gene	0.60
PTEN	therapeutic_target	gene	0.60
OGDH	therapeutic_target	gene	0.60
GBA	therapeutic_target	gene	0.60

Incoming (146)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	0.82
CD33	regulates	gene	0.70
PLD3	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
CD33	associated_with	gene	0.60
NME8	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CELF1	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MEF2C	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
JAK	expressed_in	gene	0.60
NFKB	expressed_in	gene	0.60
CDKN2A	expressed_in	gene	0.60
HSPA1A	associated_with	gene	0.60
AGER	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	interacts_with	gene	0.60
TUMOR SUPPRESSOR GENES	interacts_with	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
RIP3	therapeutic_target	gene	0.60
TBK1	associated_with	gene	0.60
FTLD	associated_with	gene	0.60
C9ORF72	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
PINK1	regulates	gene	0.60
FASL	biomarker_for	gene	0.60
FAS	biomarker_for	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
IL-17	inhibits	gene	0.60
AGING	associated_with	gene	0.60
APOE	inhibits	gene	0.60
CD44	inhibits	gene	0.60
P2RY12	inhibits	gene	0.60
AND	inhibits	gene	0.60
CD33	inhibits	gene	0.60
APOE Ε4	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HLA

Understanding Entity Pages

Wiki Pages (20)

Parkinson's Disease

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Multiple System Atrophy

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Oligodendrocytes

substantia-nigra

nlrc5-protein

deferiprone-neurodegeneration

Multiple Sclerosis (MS)

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Orexin Neurons

MSA Genetics and Risk Factors

Adaptive Immunity in Neurodegeneration

Neuromyelitis Optica Spectrum Disorder (NMOSD)

ALS Regional Onset and Spread: Network-Level Staging Model

Exosome Biogenesis in Neurodegeneration

Neuropathology of Progressive Supranuclear Palsy