Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATG17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATG17 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, associated with. Associated with Als, Cancer, Carcinoma. Connected to 22 entities in the SciDEX knowledge graph.
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| Gene Symbol | ATG17 |
| Full Name | RB1CC1/FIP200 |
| Chromosome | 8q11.23 |
| Protein Type | Scaffold Protein |
| Function | encodes a critical scaffold protein in the autophagy initiation machinery. |
| Molecular Weight | 200 kDa |
| Amino Acids | 524 aa |
| Exons | 46 |
| UniProt ID | [Q8TF72](https://www.uniprot.org/uniprot/Q8TF72) |
| Ensembl ID | ENSG00000055118 |
| OMIM | 604791 |
| GeneCards | ATG17 |
| Human Protein Atlas | ATG17 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | AUTOPHAGY, CANCER, FIP200, P53, RB1, RB1CC1 |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATG17["ATG17"]
Carcinoma{"Carcinoma"}
ATG17 -->|"expressed in"| Carcinoma
Cancer{"Cancer"}
ATG17 -->|"expressed in"| Cancer
Tumor{"Tumor"}
ATG17 -->|"expressed in"| Tumor
Als{"Als"}
ATG17 -->|"interacts with"| Als
ATG17 -->|"interacts with"| Cancer
ATG17 -->|"interacts with"| Tumor
CANCER["CANCER"]
ATG17 -->|"expressed in"| CANCER
AUTOPHAGY["AUTOPHAGY"]
ATG17 -->|"associated with"| AUTOPHAGY
LC3["LC3"]
ATG17 -->|"expressed in"| LC3
Autophagy(["Autophagy"])
ATG17 -->|"associated with"| Autophagy
ATG17 -->|"interacts with"| CANCER
RB1CC1["RB1CC1"]
ATG17 -->|"interacts with"| RB1CC1
ATG["ATG"]
ATG -->|"component of"| ATG17
LC3B["LC3B"]
LC3B -->|"expressed in"| ATG17
FIP200["FIP200"]
FIP200 -->|"expressed in"| ATG17
P62["P62"]
P62 -->|"expressed in"| ATG17
FIP200 -->|"interacts with"| ATG17
P53["P53"]
P53 -->|"interacts with"| ATG17
style ATG17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Carcinoma | expressed_in | disease | 0.65 |
| Autophagy | interacts_with | pathway | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| CANCER | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| LC3 | expressed_in | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATG17 in their description or question text
No additional research found