gene

FIP200

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIP200: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1107Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

FIP200 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, Aging. Connected to 512 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FIP200
Chromosome	6q24.2
Protein Type	Scaffold Protein
Function	is a 200 kDa scaffold protein that plays essential roles in autophagy initiation, cell adhesion, migration, and neuronal survival.
Molecular Weight	200 kDa
Amino Acids	664 aa
Pathways	Akt, Apoptosis, Autophagy, Wnt, autophagy
Ensembl ID	ENSG00000048991
GeneCards	FIP200
Human Protein Atlas	FIP200
Mitochondrial quality control	Removing damaged mitochondria through mitophagy
Protein aggregate clearance	Degrading misfolded proteins and aggregates
Synaptic maintenance	Regulating synaptic vesicle recycling and neurotransmitter release
Neuronal survival	Preventing apoptosis under cellular stress
Associated Diseases	AD, ALI, ALS, Alzheimer, Cancer
Known Drugs/Compounds	rapamycin
Interactions	RTN3, SESN2, AMBRA1, APC, PEX3, PTEN
KG Connections	1107 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FIP200["FIP200"] -->|"interacts"| LC3["LC3"]
    FIP200["FIP200"] -->|"interacts"| Dementia["Dementia"]
    FIP200["FIP200"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    FIP200["FIP200"] -->|"interacts"| Als["Als"]
    FIP200["FIP200"] -->|"interacts"| Alzheimer["Alzheimer"]
    FIP200["FIP200"] -->|"interacts"| Parkinson["Parkinson"]
    NDP52["NDP52"] -->|"interacts"| FIP200["FIP200"]
    CAT["CAT"] -->|"interacts"| FIP200["FIP200"]
    OPTN["OPTN"] -->|"interacts"| FIP200["FIP200"]
    DNM1L["DNM1L"] -->|"interacts"| FIP200["FIP200"]
    style FIP200 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (693)

Target	Relation	Type	Str
autophagy	regulates	pathway	0.90
TBK1	inhibits	protein	0.90
neurogenesis	regulates	pathway	0.90
p62	inhibits	protein	0.90
ULK1/2 COMPLEX	associated_with	protein	0.90
neural stem cells	regulates	cell_type	0.90
Autophagy	interacts_with	pathway	0.90
ULK1	interacts_with	protein	0.84
CCL5	inhibits	protein	0.80
CXCL10	inhibits	protein	0.80
NBR1	regulates	gene	0.80
OPTN	regulates	gene	0.80
RB1	regulates	gene	0.80
RB1CC1	regulates	gene	0.80
SQSTM1	regulates	gene	0.80
autophagy pathway	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
TBK1	interacts_with	gene	0.80
Mitophagy	interacts_with	pathway	0.80
Als	interacts_with	disease	0.75
Tumor	associated_with	disease	0.75
Neurodegeneration	interacts_with	disease	0.75
Als	activates	disease	0.75
LC3	interacts_with	protein	0.70
TAX1BP1	interacts_with	gene	0.70
LC3	associated_with	gene	0.70
OPTN	interacts_with	gene	0.70
ATG7	associated_with	gene	0.70
P62	interacts_with	gene	0.70
ATG16L1	associated_with	gene	0.70
RB1	associated_with	gene	0.70
JNK	regulates	gene	0.70
NDP52	regulates	gene	0.70
STING1	regulates	gene	0.70
MTOR	regulates	gene	0.70
PIK3C3	regulates	gene	0.70
TFEB	regulates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
Apoptosis	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
apoptosis	activates	process	0.70
AUTOPHAGY	associated_with	gene	0.70
MITOCHONDRIA	interacts_with	gene	0.70
AUTOPHAGY	inhibits	gene	0.70
Autophagy	inhibits	pathway	0.70
NLR	activates	gene	0.70
ROS	activates	gene	0.70
Parkinson's disease	activates	disease	0.70
oxidative stress response	participates_in	pathway	0.70
necroptosis	participates_in	pathway	0.70

Incoming (414)

Source	Relation	Type	Str
TAX1BP1	interacts_with	gene	0.90
AUTOPHAGY	interacts_with	gene	0.90
NDP52	binds	protein	0.85
TAX1BP1	binds	protein	0.85
P62	binds	protein	0.85
NDP52	interacts_with	protein	0.84
TBK1	modulates	protein	0.80
ATG	component_of	gene	0.80
PINK1	interacts_with	gene	0.80
MITOPHAGY	interacts_with	gene	0.80
PARKIN	interacts_with	gene	0.70
PTEN	interacts_with	gene	0.70
BECN1	associated_with	gene	0.70
ATG5	associated_with	gene	0.70
miR-224-3p	inhibits	gene	0.70
RB1CC1	encodes	gene	0.70
BECN1	regulates	gene	0.70
CALCOCO2	regulates	gene	0.70
DDIT3	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
ERN1	regulates	gene	0.70
ATG	interacts_with	gene	0.70
NEURODEGENERATION	interacts_with	gene	0.70
ATG	activates	gene	0.70
DNA	activates	gene	0.70
rapamycin	targets	drug	0.70
AMPK	regulates	gene	0.70
ATG	regulates	gene	0.70
DNA	regulates	gene	0.70
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FIP200

Understanding Entity Pages

Summary

Wiki Pages (21)

fip200

rapamycin-tauopathy

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

RICTOR Protein

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

autophagy-lysosome-dysfunction

GBA Gene Mutations and Parkinson's Disease Risk

Autophagy-Lysosomal Pathway

Autophagy Types in Neurodegeneration

autophagy

Autophagy-Impaired Neurons

ATG7 Protein — Autophagy-Related Protein 7

Autophagy-Lysosome Pathway in Neurodegeneration

CBS Autophagy-Lysosomal Pathway Dysfunction

CRISPRi Epigenetic Silencing of SNCA for Parkinson's Disease

Autophagy Enhancers for PD

Autophagy-Lysosomal Dysfunction Neurons

Protein Clearance Mechanisms

protein-trafficking-pathways