gene

atg2b

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about atg2b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

12Outgoing

4Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ATG2B
Full Name	Autophagy Related 2B
Chromosome	14q32.12
Protein Type	Peripheral Membrane Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	223 kDa
Pathways	PI3K
UniProt ID	[Q9P2R3](https://www.uniprot.org/uniprot/Q9P2R3)
GeneCards	ATG2B
Human Protein Atlas	ATG2B
Overlapping functions	Both proteins participate in autophagosome expansion and lipid transfer
Compensatory expression	ATG2B can compensate for ATG2A loss in many cell types
Tissue specificity	ATG2B expression is enriched in certain tissues, particularly hematopoietic cells
Knockout studies	Single knockouts of either gene are viable; double knockout is embryonic lethal
Membrane expansion	Facilitates lipid delivery to growing autophagosomes
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATG2B

gene · 638 words

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Pathway Diagram

graph TD
    ATG2B["ATG2B"]
    ATG2B -->|"activates"| Tumor["Tumor"]
    ATG2B -->|"inhibits"| Cancer["Cancer"]
    ATG2B -->|"inhibits"| Ovarian_Cancer["Ovarian Cancer"]
    ATG2B -->|"inhibits"| CANCER["CANCER"]
    ATG2B -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    ATG2B -->|"activates"| Autophagy["Autophagy"]
    ATG2B -->|"inhibits"| Chemoresistance["Chemoresistance"]
    ATG2B -->|"inhibits"| Invasion["Invasion"]
    ACETYL_COA["ACETYL-COA"] -->|"inhibits"| ATG2B
    ATG5["ATG5"] -->|"activates"| ATG2B
    SIRT1["SIRT1"] -->|"activates"| ATG2B

Outgoing (12)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG2B	data_in	dataset_row	0.00
Tumor	activates	disease	0.65
Cancer	inhibits	disease	0.65
Ovarian Cancer	inhibits	disease	0.65
Chemoresistance	inhibits	pathway	0.60
Invasion	inhibits	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
Glycolysis	inhibits	pathway	0.60
CANCER	inhibits	gene	0.60
Epigenetic	inhibits	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG2B	data_in	dataset_row	0.00
ATG5	activates	gene	0.60
SIRT1	activates	gene	0.60
ACETYL-COA	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning atg2b in their description or question text

No additional research found