Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Chemoresistance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Chemoresistance |
| Key Genes/Proteins | CANCER, AUTOPHAGY, APOPTOSIS, GENES, PI3K, AKT |
| Related Diseases | Cancer, Als, Tumor |
Knowledge base pages for this entity
graph TD
Chemoresistance["<b>Chemoresistance</b>"]
CANCER(["CANCER"])
CANCER -->|"therapeutic_target"| Chemoresistance
Cancer{"Cancer"}
Cancer -->|"therapeutic_target"| Chemoresistance
Als{"Als"}
Als -->|"therapeutic_target"| Chemoresistance
AUTOPHAGY(["AUTOPHAGY"])
AUTOPHAGY -->|"activates"| Chemoresistance
style Chemoresistance fill:#1a3a4a,stroke:#81c784,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| Als | activates | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| IDH2 | promotes | gene | 0.95 |
| PARP1-DOT1L Transcription Axis | associated_with | pathway | 0.90 |
| PRMT1 | associated_with | protein | 0.90 |
| De Novo Fatty Acid Synthesis | contributes_to | pathway | 0.90 |
| PRMT1 | promotes | protein | 0.90 |
| CANCER | associated_with | gene | 0.90 |
| Cancer | associated_with | disease | 0.90 |
| Tumor | inhibits | disease | 0.90 |
| Pyrimidine Biosynthesis | contributes_to | process | 0.85 |
| Fatty Acid Synthesis | contributes_to | pathway | 0.85 |
| Autophagy | contributes_to | process | 0.85 |
| Autophagy Inhibitors | targets | drug | 0.85 |
| Notch Signaling Pathway | associated_with | pathway | 0.85 |
| DOT1L | contributes_to | protein | 0.85 |
| Notch Signaling Pathway | promotes | pathway | 0.85 |
| PI3K/AKT/mTOR | modulates | pathway | 0.80 |
| IDH2 | associated_with | gene | 0.80 |
| JAK/STAT | contributes_to | pathway | 0.80 |
| DOT1L | associated_with | protein | 0.80 |
| Notch Signaling Pathway | contributes_to | pathway | 0.80 |
| Usp1/Parp1 Axis | involved_in | pathway | 0.80 |
| Tumor | associated_with | disease | 0.80 |
| MTOR | regulates | gene | 0.80 |
| PTEN | activates | gene | 0.80 |
| AUTOPHAGY | therapeutic_target | gene | 0.80 |
| FERROPTOSIS | therapeutic_target | gene | 0.80 |
| AKT | therapeutic_target | gene | 0.80 |
| MTOR | therapeutic_target | gene | 0.80 |
| Breast Cancer | therapeutic_target | disease | 0.80 |
| CANCER | causes | gene | 0.80 |
| Cancer | causes | disease | 0.80 |
| Colorectal Cancer | activates | disease | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||