protein

ATXN3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATXN3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Ataxin-3 (ATXN3) is a deubiquitinating enzyme encoded by the ATXN3 gene. Pathogenic CAG repeat expansions cause Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3).

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🔬 Protein Info

Gene Symbol	ATXN3PROTEIN
Aliases	MJD1, SCA3 protein, Josephin domain-containing protein 1
Chromosome	14q32.12
Protein Type	Enzyme
Function	is a deubiquitinating enzyme encoded by the ATXN3 gene.
Molecular Weight	~42 kDa
Amino Acids	364 aa
GeneCards	ATXN3PROTEIN
Human Protein Atlas	ATXN3PROTEIN
Gene	ATXN3 (Ataxin-3)
Protein	364 amino acids (normal), expanded in disease
Associated Diseases	Als, Alzheimer's disease, Ataxia, dementia, frontotemporal
Interactions	AND, ATM, ATXN2, BECN1, BMAL1, DNA
KG Connections	161 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

atxn3-protein

protein · 2995 words

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Pathway Diagram

graph TD
    ATXN3PROTEIN["ATXN3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ATXN3PROTEIN -->|"implicated_in"| neurodegeneration
    style ATXN3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ATXN3PROTEIN in their description or question text

No additional research found