Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BDNF/TRKB SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| APP | interacts_with | gene | 0.65 |
| APP | inhibits | gene | 0.65 |
| APP | degrades | gene | 0.65 |
| BDNF | associated_with | gene | 0.45 |
| TAU | associated_with | protein | 0.45 |
| BIN1 | associated_with | gene | 0.45 |
| APP | associated_with | gene | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| DEPRESSION | associated_with | disease | 0.45 |
| ANXIETY | associated_with | disease | 0.45 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.45 |
| CREB | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | inhibits | protein | 0.65 |
| NEUROINFLAMMATION | treats | phenotype | 0.65 |
| SYNAPTIC PLASTICITY | associated_with | phenotype | 0.50 |
| NEUROFIBRILLARY TANGLES | associated_with | phenotype | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||