protein

IRISIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRISIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

Summary

Page for Irisin — Exercise-Induced Myokine

View on Wiki →

🔬 Protein Info

Gene Symbol	IRISIN
Function	Irisin acts as a systemic mediator, conveying the benefits of exercise to distant tissues including the brain.
Molecular Weight	12 kDa
Amino Acids	112 aa
Pathways	Mitochondrial Function, Synaptic Plasticity
GeneCards	IRISIN
Human Protein Atlas	IRISIN
Associated Diseases	Alzheimer'S Disease, DIABETES, Insulin Sensitivity, Neurodegenerative Diseases, OBESITY, Osteoporosis
Interactions	AMPK, NFKB, FGF2, NEPRILYSIN, AMYLOID, IL-8
KG Connections	80 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IRISIN("IRISIN")
    FNDC5["FNDC5"]
    FNDC5 -->|"encodes"| IRISIN
    Angiogenesis["Angiogenesis"]
    IRISIN -->|"associated_with"| Angiogenesis
    Fracture_Healing["Fracture Healing"]
    IRISIN -->|"associated_with"| Fracture_Healing
    Insulin_Sensitivity["Insulin Sensitivity"]
    IRISIN -->|"associated_with"| Insulin_Sensitivity
    Osteogenesis["Osteogenesis"]
    IRISIN -->|"associated_with"| Osteogenesis
    NFKB("NFKB")
    IRISIN -->|"inhibits"| NFKB
    Inflammation["Inflammation"]
    IRISIN -->|"associated_with"| Inflammation
    Bone_Formation["Bone Formation"]
    IRISIN -->|"associated_with"| Bone_Formation
    Bone_Fracture_Healing["Bone Fracture Healing"]
    IRISIN -->|"associated_with"| Bone_Fracture_Healing
    Mitochondrial_Function["Mitochondrial Function"]
    IRISIN -->|"associated_with"| Mitochondrial_Function
    Oxidative_Stress["Oxidative Stress"]
    IRISIN -->|"associated_with"| Oxidative_Stress
    Osteoporosis{"Osteoporosis"}
    IRISIN -->|"protects_against"| Osteoporosis
    Amyloid_Beta_Toxicity["Amyloid-Beta Toxicity"]
    IRISIN -->|"associated_with"| Amyloid_Beta_Toxicity
    BDNF("BDNF")
    IRISIN -->|"associated_with"| BDNF
    Type_2_Diabetes{"Type 2 Diabetes"}
    IRISIN -->|"treats"| Type_2_Diabetes

Outgoing (98)

Target	Relation	Type	Str
Angiogenesis	associated_with	process	0.95
Fracture Healing	associated_with	process	0.95
Insulin Sensitivity	associated_with	phenotype	0.90
Osteogenesis	associated_with	process	0.90
NFKB	inhibits	protein	0.90
Inflammation	associated_with	process	0.90
Bone Formation	associated_with	process	0.90
Bone Fracture Healing	associated_with	process	0.90
TFEB	activates	protein	0.90
Parkinson's Disease	protects_against	disease	0.90
Neuroinflammation	inhibits	process	0.90
Mitochondrial Function	associated_with	process	0.85
Oxidative Stress	associated_with	process	0.85
Osteoporosis	protects_against	disease	0.85
Amyloid-Beta Toxicity	associated_with	process	0.85
BDNF	associated_with	protein	0.85
Type 2 Diabetes	treats	disease	0.85
Sarcopenia	treats	disease	0.85
Depression	protects_against	disease	0.85
AMPK	activates	protein	0.80
Alzheimer's Disease	treats	disease	0.80
IL-6	protects_against	protein	0.50
SCRIB	co_discussed	gene	0.50
SPARC	co_discussed	protein	0.50
STING	co_discussed	gene	0.50
IL-8	protects_against	protein	0.50
Stem Cell	associated_with	cell_type	0.50
STEM CELLS	associated_with	concept	0.50
Stem Cell	activates	cell_type	0.50
RUNX2	activates	concept	0.50
STEM CELLS	activates	concept	0.50
FGF2	activates	gene	0.50
ANGPT1	activates	concept	0.50
NEPRILYSIN	activates	protein	0.50
AMYLOID	activates	gene	0.50
Astrocytes	activates	cell_type	0.50
AMYLOID-β	activates	concept	0.50
EXERCISE	activates	concept	0.50
EXERCISE	associated_with	concept	0.50
disease	associated_with	disease	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
DIABETES	associated_with	disease	0.50
OBESITY	associated_with	disease	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
Type 2 Diabetes	associated_with	disease	0.50
Osteoporosis	associated_with	disease	0.50
Sarcopenia	associated_with	disease	0.50
oxidative stress	activates	phenotype	0.50

Incoming (21)

Source	Relation	Type	Str
FNDC5	encodes	gene	1.00
ALZHEIMER	activates	gene	0.50
BDNF	co_discussed	gene	0.50
FGF21	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
HEPSIN	co_discussed	protein	0.50
VEGF	activates	gene	0.50
BMP2	activates	gene	0.50
PDGFRB	activates	gene	0.50
VEGFB	activates	protein	0.50
STAT3	activates	gene	0.50
FNDC5	activates	gene	0.50
FNDC5	associated_with	gene	0.50
DEPRESSION	activates	disease	0.50
BDNF	activates	gene	0.50
IL-6	activates	protein	0.50
IL-1Β	activates	protein	0.50
FGF21	activates	gene	0.50
SPARC	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IRISIN

Understanding Entity Pages

Summary

Wiki Pages (20)

CBS/PSP Treatment Rankings

IGF-1 Signaling Pathway in Neurodegeneration

Epigenetic Mechanisms in Alzheimer's Disease

AMPK Signaling Pathway

Irisin (FNDC5) - Exercise-Induced Myokine for Neurodegeneration

Exercise-BDNF-Mitochondrial Resilience Hypothesis

PGC-1α (PPARGC1A)

Exercise and Physical Activity for Neuroprotection

Exercise-BDNF-Mitochondrial Resilience Hypothesis in Parkinson's Disease

AMPK Signaling in Neurodegeneration

Hepsin Protein

Exercise-Induced Myokines for Neurodegeneration Therapy

Exercise-BDNF Signaling Axis Hypothesis in Parkinson's Disease

Irisin Therapy — Exercise-Induced Myokine for Neurodegeneration

Exercise and Neuroprotection

MYH7 Gene

Follistatin/Activin/Myostatin Axis Modulator Therapy for Neurodegeneration

Exercise-Induced Neurotrophic Mechanisms in Neurodegeneration