concept

BDNF/TRKB SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BDNF/TRKB SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

1Hypotheses

1Analyses

13Outgoing

8Incoming

0Experiments

1Debates

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💡 Concept Info

Name	BDNF/TRKB SIGNALING
Key Genes/Proteins	APP, BDNF, BIN1, CREB, TAU
Related Diseases	ANXIETY, DEPRESSION, NEUROFIBRILLARY TANGLES, NEUROINFLAMMATION, OXIDATIVE STRESS

Pathway Diagram

graph TD
    BDNF_TRKB_SIGNALING[BDNF/TRKB SIGNALING]
    BDNF_TRKB_SIGNALING -->|promotes| neuroprotection[neuroprotection]
    BDNF_TRKB_SIGNALING -->|interacts| APP[APP]
    BIN1[BIN1] -->|inhibits| BDNF_TRKB_SIGNALING
    TNF[TNF] -->|disrupts| BDNF_TRKB_SIGNALING
    TAU[TAU] -->|inhibits| BDNF_TRKB_SIGNALING
    NEUROINFLAMMATION[NEUROINFLAMMATION] -->|treats| BDNF_TRKB_SIGNALING

Outgoing (13)

Target	Relation	Type	Str
neuroprotection	promotes	process	0.92
APP	degrades	gene	0.65
APP	interacts_with	gene	0.65
APP	inhibits	gene	0.65
OXIDATIVE STRESS	associated_with	phenotype	0.45
CREB	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
APP	associated_with	gene	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
DEPRESSION	associated_with	disease	0.45
ANXIETY	associated_with	disease	0.45
TAU	associated_with	protein	0.45
BIN1	associated_with	gene	0.45

Incoming (8)

Source	Relation	Type	Str
BIN1	inhibits	protein	0.80
TNF	disrupts	gene	0.70
irisin	enhances	protein	0.70
irisin	activates	protein	0.70
NEUROINFLAMMATION	treats	phenotype	0.65
TAU	inhibits	protein	0.65
SYNAPTIC PLASTICITY	associated_with	phenotype	0.50
NEUROFIBRILLARY TANGLES	associated_with	phenotype	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study demonstrates that exercise-conditioned plasma transfers cognitive bene

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning BDNF/TRKB SIGNALING in their description or question text

No additional research found