concept

BST2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BST2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

30Outgoing

4Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	BST2
Key Genes/Proteins	PEDV N, CALCOCO2, nucleocapsid protein, PEDV nucleocapsid protein, IRF1
Related Diseases	Porcine Epidemic Diarrhea Virus, PEDV, PEDV replication
Related Pathways	NFKB-dependent Antiviral Immune Response

Wiki Pages (1)

Knowledge base pages for this entity

IRF1 Gene - Interferon Regulatory Factor 1

gene · 779 words

→

Pathway Diagram

graph TD
    BST2["BST2"]
    BST2 -->|"inhibits"| Porcine_Epidemic_Diarrhea_Viru["Porcine Epidemic Diarrhea Virus"]
    BST2 -->|"binds"| PEDV_N["PEDV N"]
    BST2 -->|"inhibits"| PEDV_Replication["PEDV Replication"]
    BST2 -->|"interacts"| CALCOCO2["CALCOCO2"]
    BST2 -->|"inhibits"| PEDV["PEDV"]
    BST2 -->|"inhibits"| PEDV_replication["PEDV replication"]
    BST2 -->|"inhibits"| nucleocapsid_protein["nucleocapsid protein"]
    IRF1["IRF1"] -->|"upregulates"| BST2
    ATG5["ATG5"] -->|"binds"| BST2

Outgoing (30)

Target	Relation	Type	Str
Porcine Epidemic Diarrhea Virus	inhibits	disease	0.95
PEDV N	binds	protein	0.95
PEDV N	degrades	protein	0.95
PEDV Replication	inhibits	process	0.95
CALCOCO2	interacts_with	protein	0.90
PEDV	inhibits	disease	0.90
PEDV replication	inhibits	phenotype	0.90
nucleocapsid protein	inhibits	protein	0.90
ASTROCYTE	expressed_in	cell_type	0.90
ASTROCYTES	expressed_in	cell_type	0.90
PEDV nucleocapsid protein	binds_and_degrades	protein	0.90
NFKB-dependent Antiviral Immune Response	activates	pathway	0.80
MICROGLIA	promotes_recruitment	cell_type	0.80
microglial recruitment	promotes	process	0.80
viral_replication	inhibits	phenotype	0.72
PEDV_N_protein	interacts_with	protein	0.72
C3	activates	protein	0.64
PEDV_N_protein	activates	protein	0.64
MARCHF8	interacts_with	protein	0.64
antiviral_response	activates	phenotype	0.64
astrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
NF-kB signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
IRF1	activates	gene	0.60
CALCOCO2	regulates	gene	0.60
NDP52	regulates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
PRKCB	activates	protein	0.56
NFKB	activates	protein	0.56

Incoming (4)

Source	Relation	Type	Str
IRF1	upregulates	gene	0.90
ATG5	binds	gene	0.80
IRF1	activates	protein	0.64
ATG5	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found