gene

CACNG6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNG6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
12Outgoing
2Incoming

Summary

CACNG6 encodes TARP γ8, an auxiliary subunit of voltage-gated calcium channels. Critical for synaptic transmission, neuronal excitability, and implicated in sensory processing disorders.

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🧬 Gene Info
Gene SymbolCACNG6
Full NameCalcium voltage-gated channel auxiliary subunit gamma 6
Chromosome11p15.4
FunctionVGCC auxiliary subunit, synaptic modulation
Primary ExpressionBrain (hippocampus, cortex), sensory organs, heart
Amino Acids323 aa
Exons14
UniProt IDQ9Y5W8
NCBI Gene ID8916
Ensembl IDENSG00000140993
GeneCardsCACNG6
Human Protein AtlasCACNG6
Protein Length323 aa
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CACNG6 — AlphaFold Q9Y5W8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

CACNG6 (TARP γ8)

gene · 1329 words

CHRNA2 — Cholinergic Receptor Nicotinic Alpha 2

gene · 1005 words

CACNA2D3 Gene

gene · 871 words

Genes

index · 271 words

Pathway Diagram

graph TD
    CACNG6["<b>CACNG6</b>"]
    BIN1["BIN1"]
    CACNG6 -->|"associated with"| BIN1
    CHRNA2["CHRNA2"]
    CACNG6 -->|"therapeutic target"| CHRNA2
    CEBPA["CEBPA"]
    CACNG6 -->|"associated with"| CEBPA
    GENES["GENES"]
    CACNG6 -->|"therapeutic target"| GENES
    CNR1["CNR1"]
    CACNG6 -->|"therapeutic target"| CNR1
    CTSD["CTSD"]
    CACNG6 -->|"associated with"| CTSD
    NME1["NME1"]
    CACNG6 -->|"therapeutic target"| NME1
    CACNA1E["CACNA1E"]
    CACNG6 -->|"associated with"| CACNA1E
    CACNA2D3["CACNA2D3"]
    CACNG6 -->|"associated with"| CACNA2D3
    PRKAB1["PRKAB1"]
    CACNG6 -->|"therapeutic target"| PRKAB1
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    CACNG6 -->|"therapeutic target"| DIABETIC_RETINOPATHY
    EPAS1["EPAS1"]
    CACNG6 -->|"associated with"| EPAS1
    EPAS1 -->|"associated with"| CACNG6
    BIN1 -->|"associated with"| CACNG6
    style CACNG6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
BIN1associated_withgene0.60
CHRNA2therapeutic_targetgene0.60
CEBPAassociated_withgene0.60
CNR1therapeutic_targetgene0.60
CTSDassociated_withgene0.60

Incoming (2)

SourceRelationTypeStr
EPAS1associated_withgene0.60
BIN1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found