Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNG6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CACNG6 encodes TARP γ8, an auxiliary subunit of voltage-gated calcium channels. Critical for synaptic transmission, neuronal excitability, and implicated in sensory processing disorders.
| Gene Symbol | CACNG6 |
| Full Name | Calcium voltage-gated channel auxiliary subunit gamma 6 |
| Chromosome | 11p15.4 |
| Function | VGCC auxiliary subunit, synaptic modulation |
| Primary Expression | Brain (hippocampus, cortex), sensory organs, heart |
| Amino Acids | 323 aa |
| Exons | 14 |
| UniProt ID | Q9Y5W8 |
| NCBI Gene ID | 8916 |
| Ensembl ID | ENSG00000140993 |
| GeneCards | CACNG6 |
| Human Protein Atlas | CACNG6 |
| Protein Length | 323 aa |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CACNG6["<b>CACNG6</b>"]
BIN1["BIN1"]
CACNG6 -->|"associated with"| BIN1
CHRNA2["CHRNA2"]
CACNG6 -->|"therapeutic target"| CHRNA2
CEBPA["CEBPA"]
CACNG6 -->|"associated with"| CEBPA
GENES["GENES"]
CACNG6 -->|"therapeutic target"| GENES
CNR1["CNR1"]
CACNG6 -->|"therapeutic target"| CNR1
CTSD["CTSD"]
CACNG6 -->|"associated with"| CTSD
NME1["NME1"]
CACNG6 -->|"therapeutic target"| NME1
CACNA1E["CACNA1E"]
CACNG6 -->|"associated with"| CACNA1E
CACNA2D3["CACNA2D3"]
CACNG6 -->|"associated with"| CACNA2D3
PRKAB1["PRKAB1"]
CACNG6 -->|"therapeutic target"| PRKAB1
DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
CACNG6 -->|"therapeutic target"| DIABETIC_RETINOPATHY
EPAS1["EPAS1"]
CACNG6 -->|"associated with"| EPAS1
EPAS1 -->|"associated with"| CACNG6
BIN1 -->|"associated with"| CACNG6
style CACNG6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| BIN1 | associated_with | gene | 0.60 |
| CHRNA2 | therapeutic_target | gene | 0.60 |
| CEBPA | associated_with | gene | 0.60 |
| CNR1 | therapeutic_target | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| NME1 | therapeutic_target | gene | 0.60 |
| CACNA1E | associated_with | gene | 0.60 |
| CACNA2D3 | associated_with | gene | 0.60 |
| PRKAB1 | therapeutic_target | gene | 0.60 |
| EPAS1 | associated_with | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| DIABETIC RETINOPATHY | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||