gene

CEBPA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CEBPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

137Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CCAAT/Enhancer Binding Protein Alpha - Transcription Factor in Neurodegeneration

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🧬 Gene Info

Gene Symbol	CEBPA
Full Name	CEBPA
Aliases	CCAAT/Enhancer Binding Protein Alpha
Protein Type	Gene
Function	encodes a transcription factor belonging to the C/EBP family of basic leucine zipper (bZIP) proteins.
Primary Expression	Broad tissue distribution; high expression in liver, adipose tissue, and hematopoietic cells; moderate expression in brain (astrocytes, microglia, neu
Molecular Weight	42 kDa
Pathways	Apoptosis, Cholesterol
UniProt ID	P49715
NCBI Gene ID	1050
Ensembl ID	ENSG00000172270
OMIM	116897
GeneCards	CEBPA
Human Protein Atlas	CEBPA
Associated Diseases	ALS, Alzheimer, Multiple Sclerosis, Parkinson
KG Connections	137 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CEBPA — AlphaFold P49715 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CEBPA["CEBPA"] -->|"therapeutic target"| Multiple_Sclerosis["Multiple Sclerosis"]
    CEBPA["CEBPA"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    CEBPA["CEBPA"] -->|"regulates"| Ms["Ms"]
    CEBPA["CEBPA"] -->|"therapeutic target"| Parkinson["Parkinson"]
    CEBPA["CEBPA"] -->|"associated with"| Alzheimer["Alzheimer"]
    CEBPA["CEBPA"] -->|"associated with"| Multiple_Sclerosis["Multiple Sclerosis"]
    CEBPA["CEBPA"] -->|"associated with"| Parkinson["Parkinson"]
    CEBPA["CEBPA"] -->|"expressed in"| Parkinson["Parkinson"]
    CEBPA["CEBPA"] -->|"expressed in"| Alzheimer["Alzheimer"]
    CEBPA["CEBPA"] -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    CEBPA["CEBPA"] -->|"regulates"| ALS["ALS"]
    CEBPA["CEBPA"] -->|"regulates"| Alzheimer["Alzheimer"]
    style CEBPA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Multiple_Sclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
MIR34A	regulates	gene	0.85
HSPB1	regulates	gene	0.80
Multiple Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Parkinson	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
HSPA1A	therapeutic_target	gene	0.60
TFE3	regulates	gene	0.60
TP53	regulates	gene	0.60
SPI1	regulates	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
NME1	therapeutic_target	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D3	associated_with	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
HSPA1A	associated_with	gene	0.60
NFKB1	protects_against	gene	0.60
STAT3	regulates	gene	0.60
TNF	regulates	gene	0.60
ESR1	regulates	gene	0.60
GATA2	protects_against	gene	0.60
HSPA1A	expressed_in	gene	0.60
EGR1	protects_against	entity	0.60
NR3C1	protects_against	entity	0.60
PPARG	protects_against	entity	0.60
BANG	regulates	gene	0.60
ATF3	protects_against	gene	0.60
Nfkb	protects_against	protein	0.60
Rb	expressed_in	protein	0.60
HSPB1	therapeutic_target	gene	0.60
GENES	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
HSPB1	associated_with	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
HSPB1	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
MICRORNAS	protects_against	gene	0.60
Apoptosis	regulates	pathway	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Cholesterol	regulates	pathway	0.60

Incoming (60)

Source	Relation	Type	Str
NM1	upregulates	protein	0.90
MYO1C	upregulates	gene	0.85
Creatine Phosphate	upregulates	compound	0.85
HSPA1A	therapeutic_target	gene	0.60
SPI1	regulates	gene	0.60
EPAS1	associated_with	gene	0.60
CACNG6	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
NME1	therapeutic_target	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
CACNA1E	associated_with	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
TP53	regulates	gene	0.60
TFE3	regulates	gene	0.60
HSPA1A	expressed_in	gene	0.60
EGR1	protects_against	gene	0.60
ATF3	protects_against	gene	0.60
BANG	regulates	gene	0.60
PPARG	protects_against	gene	0.60
NR3C1	protects_against	gene	0.60
GATA2	protects_against	gene	0.60
TNF	regulates	gene	0.60
STAT3	regulates	gene	0.60
ESR1	regulates	gene	0.60
NFKB1	protects_against	gene	0.60
FOS	associated_with	gene	0.60
MYC	associated_with	gene	0.60
FOSB	expressed_in	gene	0.60
CAMK2G	expressed_in	gene	0.60
EGR1	associated_with	gene	0.60
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
HSPB1	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
HSPB1	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
MICRORNAS	protects_against	gene	0.60
AND	regulates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CEBPA

Understanding Entity Pages

Summary

Wiki Pages (14)

CEBPA Gene

Cellular Senescence in Neurodegeneration

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

CEBPE Gene

CACNG6 (TARP γ8)

CHRNA2 — Cholinergic Receptor Nicotinic Alpha 2

CACNA2D3 Gene

CACNA1E Gene

CCAAT/Enhancer Binding Protein Beta Protein

CCAAT/Enhancer Binding Protein Alpha Protein

CCAAT/Enhancer Binding Protein Delta Protein

CAMK2G — Calcium/Calmodulin-Dependent Kinase 2 Gamma