gene

PRKAB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKAB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

16Outgoing

17Incoming

0Experiments

0Debates

Summary

Comprehensive information about PRKAB1 (AMPK beta-1 subunit), its role in cellular energy homeostasis, metabolic regulation, and implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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🧬 Gene Info

Gene Symbol	PRKAB1
Full Name	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1
Aliases	AMPK beta-1 subunit
Chromosome	12q24.31
Function	is a central cellular energy sensor that plays a critical role in regulating energy homeostasis across all eukaryotic cells.
Subcellular Localization	PRKAB1 (beta-1) is the predominant isoform in most tissues
Molecular Weight	30 kDa
Amino Acids	270 aa
Pathways	AMPK, AMPK signaling
UniProt ID	Q9Y478
NCBI Gene ID	5564
Ensembl ID	ENSG00000111725
OMIM	602636
GeneCards	PRKAB1
Human Protein Atlas	PRKAB1
Associated Diseases	neurodegeneration
Interactions	AMPK, AND, Ras
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRKAB1 — AlphaFold Q9Y478 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

gene · 1741 words

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Pathway Diagram

graph TD
    PRKAB1["<b>PRKAB1</b>"]
    Obesity{"Obesity"}
    PRKAB1 -->|"inhibits"| Obesity
    Diabetes{"Diabetes"}
    PRKAB1 -->|"inhibits"| Diabetes
    PRKAB1 -->|"therapeutic target"| Diabetes
    PRKAB1 -->|"therapeutic target"| Obesity
    AMPK["AMPK"]
    PRKAB1 -->|"inhibits"| AMPK
    CACNA1E["CACNA1E"]
    PRKAB1 -->|"therapeutic target"| CACNA1E
    CNR1["CNR1"]
    PRKAB1 -->|"therapeutic target"| CNR1
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    PRKAB1 -->|"therapeutic target"| DIABETIC_RETINOPATHY
    EPAS1["EPAS1"]
    PRKAB1 -->|"therapeutic target"| EPAS1
    CTSD["CTSD"]
    PRKAB1 -->|"therapeutic target"| CTSD
    CEBPA["CEBPA"]
    PRKAB1 -->|"therapeutic target"| CEBPA
    CACNA2D3["CACNA2D3"]
    PRKAB1 -->|"therapeutic target"| CACNA2D3
    EPAS1 -->|"therapeutic target"| PRKAB1
    CACNG6["CACNG6"]
    CACNG6 -->|"therapeutic target"| PRKAB1
    BIN1["BIN1"]
    BIN1 -->|"therapeutic target"| PRKAB1
    CHRNA2["CHRNA2"]
    CHRNA2 -->|"therapeutic target"| PRKAB1
    CEBPA -->|"therapeutic target"| PRKAB1
    GENES["GENES"]
    GENES -->|"associated with"| PRKAB1
    CNR1 -->|"therapeutic target"| PRKAB1
    CTSD -->|"therapeutic target"| PRKAB1
    NME1["NME1"]
    NME1 -->|"therapeutic target"| PRKAB1
    CACNA1E -->|"therapeutic target"| PRKAB1
    CACNA2D3 -->|"therapeutic target"| PRKAB1
    AMPK -->|"inhibits"| PRKAB1
    style PRKAB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
aerobic glycolysis	inhibits	process	0.80
Obesity	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
EPAS1	therapeutic_target	gene	0.60
CTSD	therapeutic_target	gene	0.60
CEBPA	therapeutic_target	gene	0.60
CACNA2D3	therapeutic_target	gene	0.60
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60
CACNA1E	therapeutic_target	gene	0.60
Ras	inhibits	protein	0.60
CNR1	therapeutic_target	gene	0.60
AMPK	inhibits	gene	0.60
AND	inhibits	gene	0.60
NAFLD	inhibits	disease	0.50

Incoming (17)

Source	Relation	Type	Str
MIR-802	downregulates	gene	0.80
AMPK	phosphorylates	entity	0.60
AMPK	inhibits	gene	0.60
AND	inhibits	gene	0.60
AMPK	regulates	gene	0.60
EPAS1	therapeutic_target	gene	0.60
CACNG6	therapeutic_target	gene	0.60
BIN1	therapeutic_target	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
CEBPA	therapeutic_target	gene	0.60
CNR1	therapeutic_target	gene	0.60
CTSD	therapeutic_target	gene	0.60
NME1	therapeutic_target	gene	0.60
CACNA1E	therapeutic_target	gene	0.60
CACNA2D3	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
MIR802	regulates	gene	0.56

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity