concept

DIABETIC RETINOPATHY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIABETIC RETINOPATHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

405Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

DIABETIC RETINOPATHY is a concept in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with Aging, Als, Atherosclerosis. Connected to 204 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DIABETIC RETINOPATHY
Key Genes/Proteins	DIABETES MELLITUS, NEURODEGENERATION
Related Diseases	Retinopathy, Als, Diabetes, Neurodegeneration, Senescence

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    DIABETIC_RETINOPATHY -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    DIABETIC_RETINOPATHY -->|"target for"| Neuropathy["Neuropathy"]
    DIABETIC_RETINOPATHY -->|"target for"| Als["Als"]
    DIABETIC_RETINOPATHY -->|"target for"| Cancer["Cancer"]
    DIABETIC_RETINOPATHY -->|"target for"| Ms["Ms"]
    DIABETIC_RETINOPATHY -.protects against.-> Inflammation["Inflammation"]
    DIABETIC_RETINOPATHY -.protects against.-> Diabetes["Diabetes"]
    DIABETIC_RETINOPATHY -.protects against.-> Neurodegeneration["Neurodegeneration"]
    DIABETIC_RETINOPATHY -.protects against.-> Neuroinflammation["Neuroinflammation"]
    DIABETES_MELLITUS["DIABETES MELLITUS"] -->|"causes"| DIABETIC_RETINOPATHY
    NF__B_pathway["NF-kappaB pathway"] -->|"activates"| DIABETIC_RETINOPATHY
    miRNA["miRNA"] -->|"regulates"| DIABETIC_RETINOPATHY
    JAK["JAK"] -->|"target for"| DIABETIC_RETINOPATHY
    VEGF["VEGF"] -->|"target for"| DIABETIC_RETINOPATHY
    HSP90AA1["HSP90AA1"] -->|"target for"| DIABETIC_RETINOPATHY
    CANCER["CANCER"] -->|"target for"| DIABETIC_RETINOPATHY
    APOPTOSIS["APOPTOSIS"] -->|"target for"| DIABETIC_RETINOPATHY
    BCL2["BCL2"] -->|"target for"| DIABETIC_RETINOPATHY
    NF_KB["NF-KB"] -->|"target for"| DIABETIC_RETINOPATHY

Outgoing (243)

Target	Relation	Type	Str
Retinopathy	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	0.95
NEURODEGENERATION	causes	gene	0.90
Diabetes	associated_with	disease	0.85
Diabetes	activates	disease	0.85
Retinopathy	associated_with	disease	0.85
Diabetes	causes	disease	0.85
Neurodegeneration	protects_against	disease	0.75
Als	associated_with	disease	0.75
Als	interacts_with	disease	0.75
Senescence	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Diabetes	therapeutic_target	disease	0.75
Retinopathy	causes	disease	0.75
Retinopathy	activates	disease	0.75
Apoptosis	therapeutic_target	pathway	0.70
Apoptosis	activates	pathway	0.70
Mitochondrial Function	therapeutic_target	pathway	0.70
Neuropathy	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Ms	contributes_to	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Stroke	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Tumor	contributes_to	disease	0.65
Inflammation	regulates	disease	0.65
Neuropathy	associated_with	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	protects_against	disease	0.65
Retinopathy	contributes_to	disease	0.65
Diabetes	contributes_to	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Glaucoma	associated_with	disease	0.65
Als	implicated_in	disease	0.65
Hypertension	causes	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Osteoporosis	activates	disease	0.65
Atherosclerosis	activates	disease	0.65

Incoming (162)

Source	Relation	Type	Str
DIABETES MELLITUS	causes	gene	1.00
VEGF	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
NEURODEGENERATION	protects_against	gene	0.70
VEGF	protects_against	gene	0.70
APOPTOSIS	activates	gene	0.70
DIABETES MELLITUS	associated_with	gene	0.70
MITOCHONDRIA	therapeutic_target	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
CD4	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
JAK	therapeutic_target	gene	0.60
MYC	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
NF-KB	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
BAX	therapeutic_target	gene	0.60
GFAP	therapeutic_target	gene	0.60
TUBB3	therapeutic_target	gene	0.60
NGF	therapeutic_target	gene	0.60
BIN1	therapeutic_target	gene	0.60
CACNG6	therapeutic_target	gene	0.60
NME1	therapeutic_target	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
CACNA1E	therapeutic_target	gene	0.60
CNR1	therapeutic_target	gene	0.60
HIPPO	expressed_in	gene	0.60
FERROPTOSIS	regulates	gene	0.60
CHAT	protects_against	gene	0.60
SYNAPTOPHYSIN	protects_against	gene	0.60
CASP1	protects_against	gene	0.60
GFAP	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
CYTOKINES	associated_with	gene	0.60
MCC	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
MAPK8	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
GFAP	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
VDAC1	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DIABETIC RETINOPATHY

Understanding Entity Pages

Summary

Wiki Pages (20)

Tau Pathology

Litronesib (LY317615/Enzastaurin)

Retinal Biomarkers in Neurodegeneration

UNC5B — Netrin-1 Receptor

Regeneron Pharmaceuticals

Wolfram Syndrome

GDNF Signaling Pathway in Neurodegeneration

FLT1 Gene

Protein Kinase C Signaling Pathway

Protein Kinase C (PKC) Signaling in Parkinson's Disease

Retinal Imaging in Neurodegeneration

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

Pericyte Loss in Neurodegeneration

SUMOylation in Neurodegeneration

AII Amacrine Cells

Retinal Imaging in PSP (NCT07000851)

KDR Gene

Optical Coherence Tomography in Neurodegeneration