EPAS1

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPAS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive page on EPAS1 gene (HIF-2α), hypoxia response in neurodegeneration, Alzheimer's disease, Parkinson's disease, and therapeutic targeting

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graph TD
    EPAS1["EPAS1"] -->|"Interacts With"| Dementia["Dementia"]
    EPAS1["EPAS1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    EPAS1["EPAS1"] -->|"Interacts With"| Als["Als"]
    EPAS1["EPAS1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    EPAS1["EPAS1"] -->|"Interacts With"| Parkinson["Parkinson"]
    EPAS1["EPAS1"] -->|"Interacts With"| Ms["Ms"]
    EPAS1["EPAS1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    EPAS1["EPAS1"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| EPAS1["EPAS1"]
    OPTN["OPTN"] -->|"Interacts With"| EPAS1["EPAS1"]
    DNM1L["DNM1L"] -->|"Interacts With"| EPAS1["EPAS1"]
    CANX["CANX"] -->|"Interacts With"| EPAS1["EPAS1"]
    LGALS3["LGALS3"] -->|"Interacts With"| EPAS1["EPAS1"]
    style EPAS1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0