Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHRNA2 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, implicated in. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | CHRNA2 |
| Full Name | Cholinergic Receptor Nicotinic Alpha 2 |
| Chromosome | 8p21 |
| Protein Type | Receptor |
| Function | is a member of the Cys-loop receptor superfamily, which also includes GABAₐ, glycine, and 5-HT₃ receptors. |
| Primary Expression | both the central and peripheral nervous systems, where they mediate fast synaptic transmission and modulate neuronal excitability |
| Molecular Weight | 56 kDa |
| UniProt ID | [P43681](https://www.uniprot.org/uniprotkb/P43681) |
| Ensembl ID | ENSG00000120288 |
| GeneCards | CHRNA2 |
| Human Protein Atlas | CHRNA2 |
| Extracellular N-terminal domain | Contains the acetylcholine binding site |
| Transmembrane domain | Four α-helices (M1-M4) forming the ion channel pore |
| Intracellular loop | Between M3 and M4, contains phosphorylation sites |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNA2["<b>CHRNA2</b>"]
CEBPA["CEBPA"]
CHRNA2 -->|"therapeutic target"| CEBPA
GENES["GENES"]
CHRNA2 -->|"therapeutic target"| GENES
CNR1["CNR1"]
CHRNA2 -->|"therapeutic target"| CNR1
CTSD["CTSD"]
CHRNA2 -->|"therapeutic target"| CTSD
NME1["NME1"]
CHRNA2 -->|"therapeutic target"| NME1
CACNA1E["CACNA1E"]
CHRNA2 -->|"therapeutic target"| CACNA1E
CACNA2D3["CACNA2D3"]
CHRNA2 -->|"therapeutic target"| CACNA2D3
PRKAB1["PRKAB1"]
CHRNA2 -->|"therapeutic target"| PRKAB1
DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
CHRNA2 -->|"therapeutic target"| DIABETIC_RETINOPATHY
EPAS1["EPAS1"]
CHRNA2 -->|"therapeutic target"| EPAS1
neurodegeneration["neurodegeneration"]
CHRNA2 -->|"implicated in"| neurodegeneration
EPAS1 -->|"therapeutic target"| CHRNA2
CACNG6["CACNG6"]
CACNG6 -->|"therapeutic target"| CHRNA2
BIN1["BIN1"]
BIN1 -->|"therapeutic target"| CHRNA2
NME1 -->|"therapeutic target"| CHRNA2
style CHRNA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| CEBPA | therapeutic_target | gene | 0.60 |
| CNR1 | therapeutic_target | gene | 0.60 |
| CTSD | therapeutic_target | gene | 0.60 |
| NME1 | therapeutic_target | gene | 0.60 |
| CACNA1E | therapeutic_target | gene | 0.60 |
| CACNA2D3 | therapeutic_target | gene | 0.60 |
| PRKAB1 | therapeutic_target | gene | 0.60 |
| EPAS1 | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| DIABETIC RETINOPATHY | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||