CCR7

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CCR7 encodes a G protein-coupled receptor for CCL19 and CCL21, essential for immune cell trafficking to lymph nodes and neuroinflammation in Alzheimer's disease and stroke.

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graph TD
    CCR7["<b>CCR7</b>"]
    CCL21["CCL21"]
    CCR7 -->|"binds"| CCL21
    immune_cells["immune_cells"]
    CCR7 -->|"expressed in"| immune_cells
    Autoimmune{"Autoimmune"}
    CCR7 -->|"therapeutic target"| Autoimmune
    Ms{"Ms"}
    CCR7 -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    CCR7 -->|"expressed in"| Inflammation
    OPTN["OPTN"]
    CCR7 -->|"therapeutic target"| OPTN
    Immune_Response(["Immune Response"])
    CCR7 -->|"expressed in"| Immune_Response
    neurodegeneration["neurodegeneration"]
    CCR7 -->|"implicated in"| neurodegeneration
    CCL21 -->|"interacts with"| CCR7
    navarixin["navarixin"]
    navarixin -->|"inhibits"| CCR7
    OPTN -->|"therapeutic target"| CCR7
    SLC22A4["SLC22A4"]
    SLC22A4 -->|"associated with"| CCR7
    SLC22A5["SLC22A5"]
    SLC22A5 -->|"associated with"| CCR7
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"expressed in"| CCR7
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| CCR7
    LEF1["LEF1"]
    LEF1 -->|"associated with"| CCR7
    style CCR7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0