CD59

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD59: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CD59 is a GPI-anchored complement regulatory protein that inhibits MAC formation. Expressed on neurons and glia, it protects against complement-mediated neurotoxicity in MS, stroke, and AD.

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graph TD
    CD59["CD59"]
    Cancer{"Cancer"}
    CD59 -->|"therapeutic_target"| Cancer
    Tumor{"Tumor"}
    CD59 -->|"activates"| Tumor
    CANCER["CANCER"]
    CD59 -->|"therapeutic_target"| CANCER
    Complement(["Complement"])
    CD59 -->|"activates"| Complement
    Apoptosis(["Apoptosis"])
    CD59 -->|"activates"| Apoptosis
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"activates"| CD59
    FAS["FAS"]
    FAS -->|"activates"| CD59
    AND["AND"]
    AND -->|"expressed_in"| CD59
    BCL_2["BCL-2"]
    BCL_2 -->|"activates"| CD59
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| CD59
    neurodegeneration["neurodegeneration"]
    CD59 -->|"implicated_in"| neurodegeneration