pathway

JAK-STAT signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK-STAT signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

1Analyses

18Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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🔀 Pathway Info

Name	JAK-STAT signaling
Key Genes/Proteins	AKT, AKT1, ALPK1, AMPK, APC, APOE
Related Diseases	ALS, Alzheimer's disease, autism spectrum disorder
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| NF_kB_signaling["NF-kB signaling"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| TGF_beta_signaling["TGF-beta signaling"]
    style TGF_beta_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| autophagy_pathway["autophagy pathway"]
    style autophagy_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STAT3["STAT3"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style STAT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    JAK["JAK"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style JAK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"involves"| JAK_STAT_signaling["JAK-STAT signaling"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    MAPK["MAPK"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style MAPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style JAK_STAT_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (18)

Target	Relation	Type	Str
neural stem cells	active_in	cell_type	0.90
microglia	active_in	cell_type	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
astrocytes	active_in	cell_type	0.80
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.80
TGF-beta signaling	crosstalk_with	pathway	0.80
dendritic cells	active_in	cell_type	0.70
unfolded protein response	crosstalk_with	pathway	0.70
neurons	active_in	cell_type	0.70
STING expression	upregulates	protein	0.70
cGAS expression	upregulates	protein	0.70
necroptosis	crosstalk_with	pathway	0.70
autophagy pathway	crosstalk_with	pathway	0.70
MAPK signaling	crosstalk_with	pathway	0.60
macrophages	active_in	cell_type	0.60
hippocampus	active_in	brain_region	0.60
lipid metabolism	crosstalk_with	pathway	0.60
STAT3	activates	gene	0.35

Incoming (163)

Source	Relation	Type	Str
JAK	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
STAT3	participates_in	gene	0.90
PI3K	participates_in	gene	0.90
depression	involves	disease	0.80
TLR	participates_in	gene	0.80
TNF	participates_in	gene	0.80
JAK2	participates_in	gene	0.80
MAPK	participates_in	gene	0.80
AKT	participates_in	gene	0.80
microglia	active_in	cell_type	0.75
IL-6	participates_in	gene	0.75
astrocytes	active_in	cell_type	0.75
EGFR	participates_in	gene	0.70
IL6	participates_in	gene	0.70
SQSTM1	participates_in	gene	0.70
LC3	participates_in	gene	0.70
ROS	participates_in	gene	0.70
MTOR	participates_in	gene	0.70
TFEB	participates_in	gene	0.70
SRC	participates_in	gene	0.70
EGF	participates_in	gene	0.70
JNK	participates_in	gene	0.70
STAT1	participates_in	gene	0.70
JAK1	participates_in	gene	0.70
ERN1	participates_in	gene	0.70
NLR	participates_in	gene	0.70
HMGB1	participates_in	gene	0.70
AMPK	participates_in	gene	0.70
epilepsy	involves	disease	0.70
IFN	participates_in	gene	0.70
neurodegeneration	involves	disease	0.70
IL-10	participates_in	gene	0.65
SOCS3	participates_in	gene	0.65
APC	participates_in	gene	0.60
ERK	participates_in	gene	0.60
stroke	involves	disease	0.60
GFAP	participates_in	gene	0.60
LIF	participates_in	gene	0.60
PSEN	participates_in	gene	0.60
traumatic brain injury	involves	disease	0.60
autism spectrum disorder	involves	disease	0.60
Huntington's disease	involves	disease	0.60
CXCL10	participates_in	gene	0.60
TYK2	participates_in	gene	0.60
BECN1	participates_in	gene	0.60
SMAD3	participates_in	gene	0.60
ROCK	participates_in	gene	0.60
RAGE	participates_in	gene	0.60
STING	participates_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the specificity of TDP-43-induced mitochondrial DNA release for

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Related Research

Hypotheses and analyses mentioning JAK-STAT signaling in their description or question text

No additional research found