JAK-STAT signaling

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK-STAT signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| NF_kB_signaling["NF-kB signaling"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| TGF_beta_signaling["TGF-beta signaling"]
    style TGF_beta_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| autophagy_pathway["autophagy pathway"]
    style autophagy_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STAT3["STAT3"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style STAT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    JAK["JAK"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style JAK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"involves"| JAK_STAT_signaling["JAK-STAT signaling"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    MAPK["MAPK"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style MAPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style JAK_STAT_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold