Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDC37: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CDC37 is an Hsp90 co-chaperone that mediates folding and maturation of protein kinases. Client kinases include LRRK2 (PD), GSK3B/CDK5 (AD), TBK1/OPTN (ALS), and oncogenic kinases.
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| Gene Symbol | CDC37 |
| Protein Type | Chaperone |
| Function | CDC37 (Cell Division Cycle 37) is an Hsp90 co-chaperone that specifically facilitates the folding and maturation of protein kinases. |
| Primary Expression | many cancers |
| Pathways | Chaperone |
| Ensembl ID | ENSG00000105401 |
| GeneCards | CDC37 |
| Human Protein Atlas | CDC37 |
| Associated Diseases | Als, Cancer, Tumor |
| Interactions | HSP90, PINK1 |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CDC37["CDC37"]
Tumor{"Tumor"}
CDC37 -->|"implicated_in"| Tumor
Cancer{"Cancer"}
CDC37 -->|"implicated_in"| Cancer
Als{"Als"}
CDC37 -->|"implicated_in"| Als
Parkinson{"Parkinson"}
CDC37 -->|"regulates"| Parkinson
P53["P53"]
CDC37 -->|"implicated_in"| P53
CANCER["CANCER"]
CDC37 -->|"implicated_in"| CANCER
Metastasis(["Metastasis"])
CDC37 -->|"implicated_in"| Metastasis
Invasion(["Invasion"])
CDC37 -->|"implicated_in"| Invasion
Angiogenesis(["Angiogenesis"])
CDC37 -->|"implicated_in"| Angiogenesis
Chaperone(["Chaperone"])
CDC37 -->|"regulates"| Chaperone
PARKINSON["PARKINSON"]
CDC37 -->|"regulates"| PARKINSON
PINK1["PINK1"]
CDC37 -->|"interacts_with"| PINK1
HSP90["HSP90"]
CDC37 -->|"interacts_with"| HSP90
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"regulates"| CDC37
AND["AND"]
AND -->|"regulates"| CDC37| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | implicated_in | disease | 0.65 |
| Als | implicated_in | disease | 0.65 |
| Tumor | implicated_in | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| PARKINSON | regulates | gene | 0.60 |
| CANCER | implicated_in | gene | 0.60 |
| Metastasis | implicated_in | pathway | 0.60 |
| Invasion | implicated_in | pathway | 0.60 |
| Angiogenesis | implicated_in | pathway | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| Chaperone | regulates | pathway | 0.60 |
| HSP90 | interacts_with | gene | 0.60 |
| P53 | implicated_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Aggregation-prone sequences trigger HSP90-dependent conforma | 0.497 | protein-biochemistry | Do chaperones selectively recognize path |
| HSP90-CDC37 complex recognizes exposed hydrophobic clusters | 0.380 | protein-biochemistry | Do chaperones selectively recognize path |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CDC37 in their description or question text
No additional research found