protein

CFHPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFHPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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Summary

In the central nervous system, complement proteins including CFH are produced by astrocytes, microglia, and neurons.

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🔬 Protein Info

Gene Symbol	CFHPROTEIN
Function	In the central nervous system, complement proteins including CFH are produced by astrocytes, microglia, and neurons.
Subcellular Localization	</strong></td><td>Plasma, Extracellular space</td></tr>
Molecular Weight	155 kDa
Amino Acids	211 aa
GeneCards	CFHPROTEIN
Human Protein Atlas	CFHPROTEIN
Decay-accelerating activity	CFH accelerates the decay of the alternative pathway C3 convertase (C3bBb), limiting complement deposition
Host cell protection	CFH binds to host cell surfaces via glycosaminoglycans, protecting self-tissues from complement attack
Fluid-phase regulation	CFH circulates at high concentrations (0.3-0.5 mg/mL) to regulate spontaneous C3 activation in plasma
Y402H (Tyr402His)	Strong association with AMD; affects heparin and C-reactive protein binding
V62I	Decreased risk of AMD
D936E	Associated with altered complement regulation
R1210C	Linked to atypical hemolytic uremic syndrome (aHUS)
Associated Diseases	Als, Alzheimer, Atherosclerosis, Heart Failure, Neurodegeneration, Senescence
Interactions	AGING, AKT2, AUTOPHAGY, BMAL1, C1S, C3
KG Connections	69 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

cfh-protein

protein · 1201 words

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Pathway Diagram

graph TD
    CFHPROTEIN["CFHPROTEIN"]
    neurodegeneration["neurodegeneration"]
    CFHPROTEIN -->|"implicated_in"| neurodegeneration
    style CFHPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CFHPROTEIN in their description or question text

No additional research found