Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CHL1 |
| Full Name | CHL1 Neural Cell Adhesion Molecule |
| Chromosome | 3p26.3 |
| Function | encodes a neural cell adhesion molecule belonging to the L1 family of immunoglobulin superfamily CAMs. |
| Primary Expression | the nervous system: |
| Molecular Weight | 200 kDa |
| Amino Acids | 209 aa |
| UniProt ID | P0CAT4 |
| NCBI Gene ID | 10752 |
| Ensembl ID | ENSG00000113838 |
| OMIM | 300114 |
| GeneCards | CHL1 |
| Human Protein Atlas | CHL1 |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHL1["<b>CHL1</b>"]
Alzheimer{"Alzheimer"}
CHL1 -->|"therapeutic target"| Alzheimer
Als{"Als"}
CHL1 -->|"therapeutic target"| Als
Ms{"Ms"}
CHL1 -->|"therapeutic target"| Ms
neurodegeneration["neurodegeneration"]
CHL1 -->|"implicated in"| neurodegeneration
TIMP1["TIMP1"]
TIMP1 -->|"associated with"| CHL1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"therapeutic target"| CHL1
GATA2["GATA2"]
GATA2 -->|"therapeutic target"| CHL1
PDGFRB["PDGFRB"]
PDGFRB -->|"associated with"| CHL1
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
IMMUNE_INFILTRATION -->|"therapeutic target"| CHL1
style CHL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | correlates_with | disease | 0.85 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| epilepsy | targets | disease | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| VPS35 | regulates | protein | 0.90 |
| APP | mediates | protein | 0.75 |
| TIMP1 | associated_with | gene | 0.60 |
| GATA2 | therapeutic_target | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| IMMUNE INFILTRATION | therapeutic_target | gene | 0.60 |
| BACE1 | co_mentioned | gene | 0.55 |
| BACE1 | targets | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||