TIMP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TIMP1 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with Als, Alzheimer, Atherosclerosis. Connected to 56 entities in the SciDEX knowledge graph.

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graph TD
    TIMP1["<b>TIMP1</b>"]
    MMP9["MMP9"]
    TIMP1 -->|"inhibits"| MMP9
    neuropathic_pain{"neuropathic pain"}
    TIMP1 -->|"protects against"| neuropathic_pain
    Atherosclerosis{"Atherosclerosis"}
    TIMP1 -->|"expressed in"| Atherosclerosis
    Inflammation{"Inflammation"}
    TIMP1 -->|"activates"| Inflammation
    Stroke{"Stroke"}
    TIMP1 -->|"activates"| Stroke
    Als{"Als"}
    TIMP1 -->|"activates"| Als
    Ischemia{"Ischemia"}
    TIMP1 -->|"activates"| Ischemia
    Ms{"Ms"}
    TIMP1 -->|"activates"| Ms
    TIMP1 -->|"contributes to"| Ms
    Alzheimer{"Alzheimer"}
    TIMP1 -->|"therapeutic target"| Alzheimer
    TIMP1 -->|"therapeutic target"| Als
    TIMP1 -->|"therapeutic target"| Ms
    MMP1["MMP1"]
    MMP1 -->|"inhibits"| TIMP1
    EZH2["EZH2"]
    EZH2 -->|"regulates"| TIMP1
    substance_P["substance P"]
    substance_P -->|"inhibits"| TIMP1
    IL12B["IL12B"]
    IL12B -->|"expressed in"| TIMP1
    ITPR1["ITPR1"]
    ITPR1 -->|"expressed in"| TIMP1
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"expressed in"| TIMP1
    GENES["GENES"]
    GENES -->|"expressed in"| TIMP1
    ANXA2["ANXA2"]
    ANXA2 -->|"activates"| TIMP1
    ICAM1["ICAM1"]
    ICAM1 -->|"activates"| TIMP1
    CD44["CD44"]
    CD44 -->|"activates"| TIMP1
    HMOX1["HMOX1"]
    HMOX1 -->|"activates"| TIMP1
    SPP1["SPP1"]
    SPP1 -->|"activates"| TIMP1
    style TIMP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0