gene

CHRNA6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRNA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
10Outgoing
1Incoming
0Experiments

Summary

CHRNA6 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, contributes to, implicated in. Associated with Autoimmune, Cancer, Depression. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCHRNA6
Full NameCholinergic Receptor Nicotinic Alpha Subunit 6
Chromosome8p21
FunctionCHRNA6 encodes the alpha-6 subunit of nicotinic receptors.
Primary Expressionthe brain and play roles in cognitive function, attention, and motor control
UniProt ID[P31415](https://www.uniprot.org/uniprotkb/P31415/entry)
GeneCardsCHRNA6
Human Protein AtlasCHRNA6
Associated DiseasesNicotine addiction, movement disorders
InteractionsCALB2, RAB3B, GFAP
KG Connections11 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

CHRNA6 Gene

gene · 648 words

CHRNB3 Gene

gene · 2904 words

CHRNA3 Protein

protein · 521 words

Genes

index · 271 words

Pathway Diagram

graph TD
    CHRNA6["<b>CHRNA6</b>"]
    Schizophrenia{"Schizophrenia"}
    CHRNA6 -->|"inhibits"| Schizophrenia
    Cancer{"Cancer"}
    CHRNA6 -->|"contributes to"| Cancer
    Depression{"Depression"}
    CHRNA6 -->|"inhibits"| Depression
    Ms{"Ms"}
    CHRNA6 -->|"inhibits"| Ms
    Autoimmune{"Autoimmune"}
    CHRNA6 -->|"contributes to"| Autoimmune
    CANCER["CANCER"]
    CHRNA6 -->|"contributes to"| CANCER
    CALB2["CALB2"]
    CHRNA6 -->|"inhibits"| CALB2
    RAB3B["RAB3B"]
    CHRNA6 -->|"inhibits"| RAB3B
    Epigenetic(["Epigenetic"])
    CHRNA6 -->|"inhibits"| Epigenetic
    Notch(["Notch"])
    CHRNA6 -->|"contributes to"| Notch
    neurodegeneration["neurodegeneration"]
    CHRNA6 -->|"implicated in"| neurodegeneration
    GFAP["GFAP"]
    GFAP -->|"inhibits"| CHRNA6
    style CHRNA6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

TargetRelationTypeStr
Schizophreniainhibitsdisease0.65
Cancercontributes_todisease0.65
Depressioninhibitsdisease0.65
Msinhibitsdisease0.65
Autoimmunecontributes_todisease0.65

Incoming (1)

SourceRelationTypeStr
GFAPinhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found