Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHRNA6 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, contributes to, implicated in. Associated with Autoimmune, Cancer, Depression. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | CHRNA6 |
| Full Name | Cholinergic Receptor Nicotinic Alpha Subunit 6 |
| Chromosome | 8p21 |
| Function | CHRNA6 encodes the alpha-6 subunit of nicotinic receptors. |
| Primary Expression | the brain and play roles in cognitive function, attention, and motor control |
| UniProt ID | [P31415](https://www.uniprot.org/uniprotkb/P31415/entry) |
| GeneCards | CHRNA6 |
| Human Protein Atlas | CHRNA6 |
| Associated Diseases | Nicotine addiction, movement disorders |
| Interactions | CALB2, RAB3B, GFAP |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNA6["<b>CHRNA6</b>"]
Schizophrenia{"Schizophrenia"}
CHRNA6 -->|"inhibits"| Schizophrenia
Cancer{"Cancer"}
CHRNA6 -->|"contributes to"| Cancer
Depression{"Depression"}
CHRNA6 -->|"inhibits"| Depression
Ms{"Ms"}
CHRNA6 -->|"inhibits"| Ms
Autoimmune{"Autoimmune"}
CHRNA6 -->|"contributes to"| Autoimmune
CANCER["CANCER"]
CHRNA6 -->|"contributes to"| CANCER
CALB2["CALB2"]
CHRNA6 -->|"inhibits"| CALB2
RAB3B["RAB3B"]
CHRNA6 -->|"inhibits"| RAB3B
Epigenetic(["Epigenetic"])
CHRNA6 -->|"inhibits"| Epigenetic
Notch(["Notch"])
CHRNA6 -->|"contributes to"| Notch
neurodegeneration["neurodegeneration"]
CHRNA6 -->|"implicated in"| neurodegeneration
GFAP["GFAP"]
GFAP -->|"inhibits"| CHRNA6
style CHRNA6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | inhibits | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| Depression | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Autoimmune | contributes_to | disease | 0.65 |
| CALB2 | inhibits | gene | 0.60 |
| RAB3B | inhibits | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| Epigenetic | inhibits | pathway | 0.60 |
| Notch | contributes_to | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GFAP | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||