Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CSNK1D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CSNK1D encodes casein kinase 1 delta, a serine/threonine kinase involved in circadian rhythm regulation, tau phosphorylation, and neurodegenerative disease pathogenesis.
| Gene Symbol | CSNK1D |
| Full Name | Casein Kinase 1 Delta |
| Chromosome | 15q21.3 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that plays critical roles in multiple cellular processes, including circadian rhythm regulation, Wnt signaling, DNA damage response, and protein trafficking. |
| Primary Expression | Brain (hypothalamus, SCN, cortex, hippocampus), liver, lung |
| Molecular Weight | 47 kDa |
| Amino Acids | 409 aa |
| Pathways | Wnt signaling, wnt |
| UniProt ID | P48730 |
| NCBI Gene ID | 1453 |
| Ensembl ID | ENSG00000141552 |
| OMIM | 604065 |
| GeneCards | CSNK1D |
| Human Protein Atlas | CSNK1D |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Huntington's disease |
| Interactions | CSNK1E, TDP-43, GAPVD1, AMYOTROPHIC LATERAL SCLEROSIS, ALS, MOTOR NEURONS |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CSNK1D["<b>CSNK1D</b>"]
Wnt___catenin_pathway(["Wnt/beta-catenin pathway"])
CSNK1D -->|"activates"| Wnt___catenin_pathway
Hedgehog_GLI_pathway(["Hedgehog-GLI pathway"])
CSNK1D -->|"activates"| Hedgehog_GLI_pathway
SHH["SHH"]
CSNK1D -->|"regulates"| SHH
PTCH1["PTCH1"]
CSNK1D -->|"regulates"| PTCH1
Oxidative_phosphorylation["Oxidative phosphorylation"]
CSNK1D -->|"regulates"| Oxidative_phosphorylation
TDP_43["TDP-43"]
CSNK1D -->|"phosphorylates"| TDP_43
GAPVD1["GAPVD1"]
CSNK1D -->|"phosphorylates"| GAPVD1
Ciliogenesis["Ciliogenesis"]
CSNK1D -->|"participates in"| Ciliogenesis
Cell_proliferation["Cell proliferation"]
CSNK1D -->|"regulates"| Cell_proliferation
Cell_migration["Cell migration"]
CSNK1D -->|"regulates"| Cell_migration
Cell_invasion["Cell invasion"]
CSNK1D -->|"regulates"| Cell_invasion
HLA_A["HLA-A"]
CSNK1D -->|"associated with"| HLA_A
MOTOR_NEURONS["MOTOR NEURONS"]
MOTOR_NEURONS -->|"inhibits"| CSNK1D
style CSNK1D fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Wnt/β-catenin pathway | activates | pathway | 0.80 |
| Hedgehog-GLI pathway | activates | pathway | 0.80 |
| SHH | regulates | gene | 0.80 |
| PTCH1 | regulates | gene | 0.80 |
| Oxidative phosphorylation | regulates | biological_process | 0.80 |
| TDP-43 | phosphorylates | protein | 0.80 |
| GAPVD1 | phosphorylates | protein | 0.80 |
| Ciliogenesis | participates_in | biological_process | 0.80 |
| Cell proliferation | regulates | biological_process | 0.80 |
| Cell migration | regulates | biological_process | 0.80 |
| Cell invasion | regulates | biological_process | 0.80 |
| HLA-A | associated_with | protein | 0.70 |
| Als | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | inhibits | disease | 0.65 |
| CSNK1E | inhibits | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | inhibits | gene | 0.60 |
| ALS | inhibits | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MOTOR NEURONS | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||