Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HLA-A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HLA class I gene involved in immune surveillance, antigen presentation, and neurodegenerative disease risk
| Gene Symbol | HLA |
| Primary Expression | Ca1, Cortex |
| Pathways | Jak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response |
| GeneCards | HLA |
| Human Protein Atlas | HLA |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's disease, Cardiovascular |
| Interactions | CANCER, P53, IL-23, AND, GENES, HSPA1A |
| KG Connections | 307 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HLA_A["HLA-A"]
HLA_A -->|"interacts"| Cancer["Cancer"]
HLA_A -->|"interacts"| Tumor["Tumor"]
HLA_A -->|"interacts"| P53["P53"]
HLA_A -->|"interacts"| HLA["HLA"]
HLA_A -->|"interacts"| AND["AND"]
HLA_A -->|"interacts"| GENES["GENES"]
HLA_A -->|"target for"| T_Cell["T Cell"]
CANCER["CANCER"] -->|"interacts"| HLA_A
TUMOR_SUPPRESSOR_GENES["TUMOR SUPPRESSOR GENES"] -->|"interacts"| HLA_A
P53 -->|"interacts"| HLA_A
TP53["TP53"] -->|"interacts"| HLA_A| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | promotes | phenotype | 0.90 |
| MAPT | modulates | gene | 0.88 |
| Neuron | expressed_in | cell_type | 0.88 |
| Cancer | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| P53 | interacts_with | gene | 0.60 |
| HLA | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| T Cell | therapeutic_target | cell_type | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
| TP53 | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||