gene

DNAJA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

16Outgoing

1Incoming

0Experiments

0Debates

Summary

DNAJA3 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, regulates, interacts with. Associated with Cancer, Lymphoma, Tumor. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNAJA3
Chromosome	16p13.3
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	High in heart, muscle, brain
Subcellular Localization	mitochondria that functions as a co-chaperone for mitochondrial Hsp70 (mtHsp70, also known as GRP75/mortalin). It is inv
Molecular Weight	52 kDa
Amino Acids	480 aa
Pathways	NF-κB
UniProt ID	Q9Y5W1
GeneCards	DNAJA3
Human Protein Atlas	DNAJA3
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, CANCER, GENES, HDAC6, HSPA1A, HSPA8
KG Connections	17 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNAJA3 — AlphaFold Q9Y5W1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNAJA3 Gene

gene · 599 words

→

DNAJA3 Protein

protein · 1333 words

→

Pathway Diagram

graph TD
    DNAJA3["DNAJA3"]
    Lymphoma{"Lymphoma"}
    DNAJA3 -->|"inhibits"| Lymphoma
    Cancer{"Cancer"}
    DNAJA3 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    DNAJA3 -->|"inhibits"| Tumor
    MYC["MYC"]
    DNAJA3 -->|"regulates"| MYC
    CANCER["CANCER"]
    DNAJA3 -->|"inhibits"| CANCER
    APOPTOSIS["APOPTOSIS"]
    DNAJA3 -->|"inhibits"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    DNAJA3 -->|"inhibits"| Apoptosis
    NF__B["NF-KappaB"]
    DNAJA3 -->|"regulates"| NF__B
    HSP70["HSP70"]
    DNAJA3 -->|"regulates"| HSP70
    HSPA1A["HSPA1A"]
    DNAJA3 -->|"interacts with"| HSPA1A
    HSPA8["HSPA8"]
    DNAJA3 -->|"interacts with"| HSPA8
    Nf__b(["Nf-Kappab"])
    DNAJA3 -->|"regulates"| Nf__b
    HDAC6["HDAC6"]
    HDAC6 -->|"inhibits"| DNAJA3
    style DNAJA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Lymphoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Infection	interacts_with	disease	0.65
HSP70	regulates	gene	0.60
HSPA1A	interacts_with	gene	0.60
MYC	regulates	gene	0.60
GENES	interacts_with	gene	0.60
Chaperone	regulates	pathway	0.60
HSPA8	interacts_with	gene	0.60
NF-ΚB	regulates	gene	0.60
Nf-Κb	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
HDAC6	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJA3 in their description or question text

No additional research found