gene

DVL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DVL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
6Outgoing
5Incoming

Summary

DVL2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in. Associated with Inflammation, Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDVL2
Full NameDishevelled Segment Polarity Protein 2
Chromosome17p13.1
Protein FamilyDishevelled (Dvl)
Protein TypeScaffold Protein
FunctionWnt signaling: Central mediator of canonical and non-canonical Wnt pathways
Molecular Weight82 kDa
Amino Acids740 aa
Exons15
PathwaysWnt
UniProt IDO14681
NCBI Gene ID1656
Ensembl IDENSG00000104164
OMIM601369
GeneCardsDVL2
Human Protein AtlasDVL2
Associated Diseasesneurodegeneration
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

DVL2 — Dishevelled Segment Polarity Protein 2

gene · 2335 words

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

mechanism · 4664 words

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 3146 words

DVL3 — Dishevelled Segment Polarity Protein 3

gene · 2849 words

FZD10 Gene

gene · 2758 words

FZD8 Gene

gene · 2717 words

Pathway Diagram

graph TD
    DVL2["<b>DVL2</b>"]
    Ms{"Ms"}
    DVL2 -->|"therapeutic target"| Ms
    Inflammation{"Inflammation"}
    DVL2 -->|"therapeutic target"| Inflammation
    P38["P38"]
    DVL2 -->|"therapeutic target"| P38
    STAT6["STAT6"]
    DVL2 -->|"therapeutic target"| STAT6
    Akt(["Akt"])
    DVL2 -->|"therapeutic target"| Akt
    Mtor(["Mtor"])
    DVL2 -->|"therapeutic target"| Mtor
    neurodegeneration["neurodegeneration"]
    DVL2 -->|"implicated in"| neurodegeneration
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| DVL2
    ERK["ERK"]
    ERK -->|"therapeutic target"| DVL2
    AKT["AKT"]
    AKT -->|"therapeutic target"| DVL2
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic target"| DVL2
    style DVL2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

TargetRelationTypeStr
Mstherapeutic_targetdisease0.65
Inflammationtherapeutic_targetdisease0.65
P38therapeutic_targetgene0.60
STAT6therapeutic_targetgene0.60
Akttherapeutic_targetpathway0.60

Incoming (5)

SourceRelationTypeStr
MTORtherapeutic_targetgene0.60
AKTtherapeutic_targetgene0.60
DCXexpressed_ingene0.60
ERKtherapeutic_targetgene0.60
INFLAMMATIONtherapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found