Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DVL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DVL2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in. Associated with Inflammation, Ms. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | DVL2 |
| Full Name | Dishevelled Segment Polarity Protein 2 |
| Chromosome | 17p13.1 |
| Protein Family | Dishevelled (Dvl) |
| Protein Type | Scaffold Protein |
| Function | Wnt signaling: Central mediator of canonical and non-canonical Wnt pathways |
| Molecular Weight | 82 kDa |
| Amino Acids | 740 aa |
| Exons | 15 |
| Pathways | Wnt |
| UniProt ID | O14681 |
| NCBI Gene ID | 1656 |
| Ensembl ID | ENSG00000104164 |
| OMIM | 601369 |
| GeneCards | DVL2 |
| Human Protein Atlas | DVL2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DVL2["<b>DVL2</b>"]
Ms{"Ms"}
DVL2 -->|"therapeutic target"| Ms
Inflammation{"Inflammation"}
DVL2 -->|"therapeutic target"| Inflammation
P38["P38"]
DVL2 -->|"therapeutic target"| P38
STAT6["STAT6"]
DVL2 -->|"therapeutic target"| STAT6
Akt(["Akt"])
DVL2 -->|"therapeutic target"| Akt
Mtor(["Mtor"])
DVL2 -->|"therapeutic target"| Mtor
neurodegeneration["neurodegeneration"]
DVL2 -->|"implicated in"| neurodegeneration
MTOR["MTOR"]
MTOR -->|"therapeutic target"| DVL2
ERK["ERK"]
ERK -->|"therapeutic target"| DVL2
AKT["AKT"]
AKT -->|"therapeutic target"| DVL2
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"therapeutic target"| DVL2
style DVL2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| DCX | expressed_in | gene | 0.60 |
| ERK | therapeutic_target | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||