gene

STAT6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

321Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive coverage of STAT6 in cytokine signaling, immune function, neuroinflammation, and implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

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🧬 Gene Info

Gene Symbol	STAT6
Full Name	Signal Transducer and Activator of Transcription 6
Chromosome	12q13.3
Protein Type	Transcription Factor
Function	is a transcription factor activated specifically by interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor signaling.
Amino Acids	847 aa
Gene Type	Protein coding
Pathways	Akt, Apoptosis, Blood-Brain Barrier, Differentiation, Dna Repair
UniProt ID	P42262
NCBI Gene ID	6778
Ensembl ID	ENSG00000141510
OMIM	601512
GeneCards	STAT6
Human Protein Atlas	STAT6
Associated Diseases	ALS, Asthma, Inflammation, Neuroinflammation
Known Drugs/Compounds	BENVITIMOD, curcumin, Curcumin
Interactions	ARNT, JUN, HDAC5, OCLN, AHR, CLDN1
KG Connections	321 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAT6 — AlphaFold P42262 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAT6["STAT6"]
    STAT6 -->|"inhibits"| Als["Als"]
    STAT6 -->|"activates"| Cancer["Cancer"]
    STAT6 -->|"activates"| Carcinoma["Carcinoma"]
    STAT6 -->|"activates"| Tumor["Tumor"]
    STAT6 -->|"expressed in"| Ms["Ms"]
    STAT6 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    STAT6 -->|"activates"| Inflammation["Inflammation"]
    BENVITIMOD["BENVITIMOD"] -->|"inhibits"| STAT6
    HDAC5["HDAC5"] -->|"regulates"| STAT6
    CLDN1["CLDN1"] -->|"inhibits"| STAT6
    NRF2["NRF2"] -->|"inhibits"| STAT6
    ARNT["ARNT"] -->|"activates"| STAT6
    AHR["AHR"] -->|"activates"| STAT6
    OCLN["OCLN"] -->|"inhibits"| STAT6
    SLC7A11["SLC7A11"] -->|"activates"| STAT6
    CLDN4["CLDN4"] -->|"inhibits"| STAT6

Outgoing (188)

Target	Relation	Type	Str
SLC7A11	upregulates	gene	0.95
DNA repair	promotes	process	0.92
homologous recombination	activates	pathway	0.88
Inflammation	activates	disease	0.85
Carcinoma	activates	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Nf-Κb	activates	pathway	0.70
Addiction	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	regulates	disease	0.65
Als	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Glioblastoma	activates	disease	0.65
ALS	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Neuroinflammation	implicated_in	disease	0.65
Stroke	protects_against	disease	0.65
Als	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Inflammation	expressed_in	disease	0.65
Asthma	causes	disease	0.65
Als	causes	disease	0.65
Inflammation	causes	disease	0.65
Aging	activates	disease	0.65
Senescence	protects_against	disease	0.65
ALS	causes	disease	0.65
Ischemia	activates	disease	0.65
SLC7A11	activates	gene	0.64
ARNT	activates	gene	0.60
JAK1	expressed_in	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
STAT3	expressed_in	gene	0.60
JAK1	biomarker_for	gene	0.60
EPHA4	expressed_in	gene	0.60

Incoming (133)

Source	Relation	Type	Str
HDAC5	associated_with	gene	0.90
Curcumin	activates	drug	0.85
AKT	activates	gene	0.70
P38	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
NF-ΚB	activates	gene	0.70
BENVITIMOD	inhibits	drug	0.64
HDAC5	regulates	protein	0.64
CLDN1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
ARNT	activates	gene	0.60
AHR	activates	gene	0.60
OCLN	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
HDAC5	activates	gene	0.60
JAK3	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
STAT1	expressed_in	gene	0.60
TNF	activates	gene	0.60
NPY1R	associated_with	gene	0.60
NPY	associated_with	gene	0.60
BDNF	contributes_to	gene	0.60
MTOR	activates	gene	0.60
DVL2	therapeutic_target	gene	0.60
VEGF	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
NQO1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
SIRT1	therapeutic_target	gene	0.60
TAU	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
ACSL4	associated_with	gene	0.60
FOXP3	inhibits	gene	0.60
MCC	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
GBM	activates	gene	0.60
TRIM28	activates	gene	0.60
JAK1	biomarker_for	gene	0.60
MERTK	expressed_in	gene	0.60
S100A9	regulates	gene	0.60
ATG5	activates	gene	0.60
SQSTM1	activates	gene	0.60
SOCS1	activates	gene	0.60
CEBPB	activates	gene	0.60
P62	activates	gene	0.60
JAK1	activates	gene	0.60
BCL2L12	activates	gene	0.60
BCL2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

STAT6

Understanding Entity Pages

Summary

Wiki Pages (21)

STAT6 — Signal Transducer and Activator of Transcription 6

TGF-β Signaling in Parkinson's Disease

JAK-STAT Signaling Pathway in Neurodegeneration

Neuroinflammation Microglia

Microglia Activation Mechanism

Interferon Signaling in Neurodegeneration

IL13 — Interleukin 13

DVL2 — Dishevelled Segment Polarity Protein 2

Microglial Polarization

STAT4 Gene

NPY1R Gene

Transcription Regulation Pathway

MRC1 — Mannose Receptor C Type 1

ARG1 — Arginase 1

HDAC5 (Histone Deacetylase 5) Protein

JAK3 Gene

MEF2D — Myocyte Enhancer Factor 2D

STAT5A Gene

HDAC5 Gene