gene

DCX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

134Connections
0Hypotheses
0Analyses
50Outgoing
35Incoming

Summary

DCX is a gene implicated in neurodegeneration research. Key relationships include: activates, causes, implicated in. Associated with AD, ADH, ALI. Connected to 57 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDCX
Full NameDoublecortin
ChromosomeXq23
Functionencodes a microtubule-associated protein essential for neuronal migration and cortical layering during fetal brain development.
Primary Expressionadult neurogenic niches where it regulates neuronal differentiation, and its dysfunction has been implicated in [Alzheimer's disease](/diseases/alzhei
Amino Acids366 aa
PathwaysAkt, Amyloid, Dendritic Spine, Differentiation, MAPK signaling
UniProt ID[O43502](https://www.uniprot.org/uniprot/O43502)
Ensembl IDENSG00000077279
GeneCardsDCX
Human Protein AtlasDCX
PKASer297, Ser302 — reduces microtubule binding
[CDK5](/proteins/cdk5)Ser297 — disrupts neuronal migration
MARK kinasesSer322 — destabilizes microtubules
Associated DiseasesAD, ADH, ALI, ALS, AMI
InteractionsCDK5, DAB1, BDNF, HES1, NESTIN, NOTCH1
KG Connections134 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

DCX Gene

gene · 1007 words

nimodipine-als

clinical_trial · 5778 words

RNA Metabolism Dysregulation in Alzheimer's Disease

mechanism · 4024 words

Neurogenesis

cell · 3757 words

amiloride-als

clinical_trial · 3477 words

Amyotrophic Lateral Sclerosis (ALS)

disease · 3458 words

Pathway Diagram

graph TD
    DCX["<b>DCX</b>"]
    Ms{"Ms"}
    DCX -->|"interacts with"| Ms
    Als{"Als"}
    DCX -->|"interacts with"| Als
    Ischemia{"Ischemia"}
    DCX -->|"activates"| Ischemia
    DCX -->|"activates"| Als
    DCX -->|"associated with"| Als
    DCX -->|"activates"| Ms
    Stroke{"Stroke"}
    DCX -->|"activates"| Stroke
    ALS{"ALS"}
    DCX -->|"causes"| ALS
    CDK5["CDK5"]
    DCX -->|"interacts with"| CDK5
    LIS1["LIS1"]
    DCX -->|"associated with"| LIS1
    DAB1["DAB1"]
    DCX -->|"interacts with"| DAB1
    PAFAH1B1["PAFAH1B1"]
    DCX -->|"associated with"| PAFAH1B1
    PAFAH1B1 -->|"associated with"| DCX
    DAB1 -->|"interacts with"| DCX
    NGF["NGF"]
    NGF -->|"activates"| DCX
    CDK5 -->|"associated with"| DCX
    DAB1 -->|"associated with"| DCX
    NESTIN["NESTIN"]
    NESTIN -->|"activates"| DCX
    CDK5 -->|"causes"| DCX
    AXON["AXON"]
    AXON -->|"causes"| DCX
    LIS1 -->|"causes"| DCX
    NEURON["NEURON"]
    NEURON -->|"causes"| DCX
    REELIN["REELIN"]
    REELIN -->|"causes"| DCX
    AND["AND"]
    AND -->|"causes"| DCX
    style DCX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (99)

TargetRelationTypeStr
Lissencephaly Type 1causesdisease0.95
Nucleokinesisinvolved_inprocess0.90
nucleokinesisregulatesprocess0.90
Type 1 Lissencephalycausesdisease0.85
Microtubulesinteracts_withcompound0.85

Incoming (35)

SourceRelationTypeStr
PAFAH1B1associated_withgene0.60
DAB1interacts_withgene0.60
NGFactivatesgene0.60
CDK5associated_withgene0.60
DAB1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found