Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DCX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DCX is a gene implicated in neurodegeneration research. Key relationships include: activates, causes, implicated in. Associated with AD, ADH, ALI. Connected to 57 entities in the SciDEX knowledge graph.
| Gene Symbol | DCX |
| Full Name | Doublecortin |
| Chromosome | Xq23 |
| Function | encodes a microtubule-associated protein essential for neuronal migration and cortical layering during fetal brain development. |
| Primary Expression | adult neurogenic niches where it regulates neuronal differentiation, and its dysfunction has been implicated in [Alzheimer's disease](/diseases/alzhei |
| Amino Acids | 366 aa |
| Pathways | Akt, Amyloid, Dendritic Spine, Differentiation, MAPK signaling |
| UniProt ID | [O43502](https://www.uniprot.org/uniprot/O43502) |
| Ensembl ID | ENSG00000077279 |
| GeneCards | DCX |
| Human Protein Atlas | DCX |
| PKA | Ser297, Ser302 — reduces microtubule binding |
| [CDK5](/proteins/cdk5) | Ser297 — disrupts neuronal migration |
| MARK kinases | Ser322 — destabilizes microtubules |
| Associated Diseases | AD, ADH, ALI, ALS, AMI |
| Interactions | CDK5, DAB1, BDNF, HES1, NESTIN, NOTCH1 |
| KG Connections | 134 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DCX["<b>DCX</b>"]
Ms{"Ms"}
DCX -->|"interacts with"| Ms
Als{"Als"}
DCX -->|"interacts with"| Als
Ischemia{"Ischemia"}
DCX -->|"activates"| Ischemia
DCX -->|"activates"| Als
DCX -->|"associated with"| Als
DCX -->|"activates"| Ms
Stroke{"Stroke"}
DCX -->|"activates"| Stroke
ALS{"ALS"}
DCX -->|"causes"| ALS
CDK5["CDK5"]
DCX -->|"interacts with"| CDK5
LIS1["LIS1"]
DCX -->|"associated with"| LIS1
DAB1["DAB1"]
DCX -->|"interacts with"| DAB1
PAFAH1B1["PAFAH1B1"]
DCX -->|"associated with"| PAFAH1B1
PAFAH1B1 -->|"associated with"| DCX
DAB1 -->|"interacts with"| DCX
NGF["NGF"]
NGF -->|"activates"| DCX
CDK5 -->|"associated with"| DCX
DAB1 -->|"associated with"| DCX
NESTIN["NESTIN"]
NESTIN -->|"activates"| DCX
CDK5 -->|"causes"| DCX
AXON["AXON"]
AXON -->|"causes"| DCX
LIS1 -->|"causes"| DCX
NEURON["NEURON"]
NEURON -->|"causes"| DCX
REELIN["REELIN"]
REELIN -->|"causes"| DCX
AND["AND"]
AND -->|"causes"| DCX
style DCX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Lissencephaly Type 1 | causes | disease | 0.95 |
| Nucleokinesis | involved_in | process | 0.90 |
| nucleokinesis | regulates | process | 0.90 |
| Type 1 Lissencephaly | causes | disease | 0.85 |
| Microtubules | interacts_with | compound | 0.85 |
| Ischemia | activates | disease | 0.75 |
| Als | activates | disease | 0.75 |
| BDNF | activates | gene | 0.70 |
| neuroinflammation | activates | disease | 0.70 |
| Ms | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Als | causes | disease | 0.65 |
| CDK5 | interacts_with | gene | 0.60 |
| LIS1 | associated_with | gene | 0.60 |
| DAB1 | interacts_with | gene | 0.60 |
| PAFAH1B1 | associated_with | gene | 0.60 |
| HES1 | activates | gene | 0.60 |
| NESTIN | activates | gene | 0.60 |
| NOTCH1 | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| TRKB | activates | gene | 0.60 |
| DYNEIN | causes | gene | 0.60 |
| PAFAH1B1 | causes | gene | 0.60 |
| DAB1 | causes | gene | 0.60 |
| REELIN | causes | gene | 0.60 |
| CDK5 | causes | gene | 0.60 |
| LIS1 | causes | gene | 0.60 |
| APP | activates | gene | 0.60 |
| SMAD4 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| Dendritic Spine | activates | pathway | 0.60 |
| SMAD2 | activates | gene | 0.60 |
| Dynein | causes | protein | 0.60 |
| Tubulin | activates | protein | 0.60 |
| Presenilin | activates | protein | 0.60 |
| PSD95 | activates | gene | 0.60 |
| GFAP | expressed_in | gene | 0.60 |
| IBA1 | expressed_in | gene | 0.60 |
| TNF | expressed_in | gene | 0.60 |
| SOX2 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| VEGF | activates | gene | 0.60 |
| IBA1 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PAFAH1B1 | associated_with | gene | 0.60 |
| DAB1 | interacts_with | gene | 0.60 |
| NGF | activates | gene | 0.60 |
| CDK5 | associated_with | gene | 0.60 |
| DAB1 | associated_with | gene | 0.60 |
| NESTIN | activates | gene | 0.60 |
| CDK5 | causes | gene | 0.60 |
| LIS1 | causes | gene | 0.60 |
| REELIN | causes | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| PSD95 | activates | gene | 0.60 |
| DAB1 | causes | gene | 0.60 |
| DYNEIN | causes | gene | 0.60 |
| TRKB | activates | gene | 0.60 |
| TUBULIN | activates | gene | 0.60 |
| SMAD1 | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| PAFAH1B1 | causes | gene | 0.60 |
| SMAD4 | activates | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| CD63 | activates | gene | 0.60 |
| AXON | causes | gene | 0.60 |
| NEURON | causes | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| CREB | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| PRESENILIN | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| MICROTUBULES | causes | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| APP/PS1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||