SARM1

Understanding Entity Pages

This page aggregates everything SciDEX knows about SARM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SARM1 is a protein involved in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Alzheimer's disease, Cancer. Connected to 29 entities in the SciDEX knowledge graph.

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graph TD
    SARM1["<b>SARM1</b>"]
    axonal_degeneration(["axonal degeneration"])
    SARM1 -->|"activates"| axonal_degeneration
    neuroinflammation(["neuroinflammation"])
    SARM1 -->|"regulates"| neuroinflammation
    Alzheimer_s_disease{"Alzheimer's disease"}
    SARM1 -->|"associated with"| Alzheimer_s_disease
    hippocampal_neurons["hippocampal neurons"]
    SARM1 -->|"expressed in"| hippocampal_neurons
    Ms{"Ms"}
    SARM1 -->|"activates"| Ms
    AND["AND"]
    SARM1 -->|"activates"| AND
    DLK["DLK"]
    SARM1 -->|"activates"| DLK
    PUMA["PUMA"]
    SARM1 -->|"activates"| PUMA
    Apoptosis(["Apoptosis"])
    SARM1 -->|"activates"| Apoptosis
    Mapk(["Mapk"])
    SARM1 -->|"activates"| Mapk
    TNF["TNF"]
    TNF -->|"inhibits"| SARM1
    NAD["NAD"]
    NAD -->|"activates"| SARM1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| SARM1
    AXON["AXON"]
    AXON -->|"activates"| SARM1
    BAX["BAX"]
    BAX -->|"activates"| SARM1
    style SARM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0