concept

EXTRACELLULAR MATRIX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXTRACELLULAR MATRIX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

136Connections

0Hypotheses

1Analyses

30Outgoing

50Incoming

0Experiments

1Debates

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Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Extracellular Matrix and Perineuronal Nets in 4R-Tauopathies

mechanism · 1593 words

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Pathway Diagram

graph TD
    EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"]
    EXTRACELLULAR_MATRIX -->|"regulates"| Vascular_Homeostasis["Vascular Homeostasis"]
    EXTRACELLULAR_MATRIX -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    EXTRACELLULAR_MATRIX -->|"contributes to"| Vascular_Disease["Vascular Disease"]
    EXTRACELLULAR_MATRIX -->|"regulates"| Vessel_Remodelling["Vessel Remodelling"]
    EXTRACELLULAR_MATRIX -->|"involved_in"| Vascular_Development["Vascular Development"]
    EXTRACELLULAR_MATRIX -->|"involved_in"| Radioresistance["Radioresistance"]
    EXTRACELLULAR_MATRIX -->|"modulates"| Disease_Initiation["Disease Initiation"]
    PERLECAN["PERLECAN"] -->|"component_of"| EXTRACELLULAR_MATRIX
    LOXL3["LOXL3"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    LOX_FAMILY["LOX FAMILY"] -->|"regulates"| EXTRACELLULAR_MATRIX
    ECM_Producing_Cells["ECM-Producing Cells"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    LOX["LOX"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    Lysyl_Oxidase["Lysyl Oxidase"] -->|"modulates"| EXTRACELLULAR_MATRIX
    JUN["JUN"] -->|"inhibits"| EXTRACELLULAR_MATRIX
    HAPLN4["HAPLN4"] -->|"participates in"| EXTRACELLULAR_MATRIX

Outgoing (30)

Target	Relation	Type	Str
Vascular Disease	associated_with	disease	0.95
Vascular Homeostasis	regulates	process	0.95
Vascular Disease	contributes_to	disease	0.90
Vessel Remodelling	regulates	process	0.90
Neurovascular Unit	component_of	process	0.90
Cancer Cell Proliferation	associated_with	phenotype	0.90
Disease Progression	contributes_to	process	0.88
Disease Initiation	contributes_to	process	0.88
Vascular Development	involved_in	process	0.88
fibrosis	contributes_to	phenotype	0.88
Angiogenesis	associated_with	process	0.85
Disease Initiation	modulates	process	0.85
Disease Progression	modulates	process	0.85
Vascular Ageing	involved_in	phenotype	0.85
Colorectal Cancer	involved_in	disease	0.85
Chronic Kidney Disease	involved_in	disease	0.85
Radioresistance	contributes_to	phenotype	0.85
Radioresistance	involved_in	phenotype	0.85
Immune Evasion	associated_with	phenotype	0.80
ALS	involved_in	disease	0.80
Prostate Cancer	regulates	disease	0.80
Vascular Ageing	contributes_to	phenotype	0.80
synaptic remodeling	regulates	process	0.70
C1q deposition	regulates	process	0.70
C3 deposition	regulates	process	0.70
Neurite Outgrowth	regulates	process	0.70
CELL MIGRATION	activates	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
WNT SIGNALING	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50

Incoming (106)

Source	Relation	Type	Str
PERLECAN	component_of	protein	0.95
Microglia	degrades	cell_type	0.95
LOXL3	involved_in	gene	0.95
ECM-Producing Cells	involved_in	cell_type	0.90
LOX FAMILY	regulates	gene	0.90
HSPG2	involved_in	protein	0.90
Lysyl Oxidase	modulates	enzyme	0.90
Integrin	interacts_with	receptor	0.88
Environmental Cues	modulates	process	0.85
Integrins	interacts_with	receptor	0.85
Car-T Cell	inhibits	cell_type	0.85
programmed cell death	associated_with	process	0.80
Cell-Matrix Interactions	interacts_with	process	0.80
JUN	inhibits	protein	0.80
HAPLN4	participates_in	gene	0.80
MMP9	remodels	gene	0.80
HAPLN4	participates_in	gene	0.70
SNCA triplication	modulates	gene	0.70
OSR2	regulates	gene	0.70
Macrophage	interacts_with	cell_type	0.50
MOTOR NEURONS	activates	concept	0.50
NEURONS	activates	concept	0.50
SYNAPSE	associated_with	concept	0.50
Astrocyte	inhibits	cell_type	0.50
MYELIN	inhibits	concept	0.50
Proteostasis	interacts_with	process	0.50
Proteins	interacts_with	protein	0.50
inflammation	associated_with	pathway	0.50
inflammation	interacts_with	pathway	0.50
aging	interacts_with	phenotype	0.50
Fibroblast	interacts_with	cell_type	0.50
Reactive Oxygen Species	interacts_with	process	0.50
FIBROBLASTS	interacts_with	concept	0.50
MACROPHAGES	interacts_with	concept	0.50
OVERVIEW	associated_with	gene	0.50
YAP1	associated_with	gene	0.50
oxidative stress	interacts_with	phenotype	0.50
Astrocytes	activates	cell_type	0.50
Neuroinflammation	associated_with	process	0.50
APOE	associated_with	gene	0.50
LRP1	associated_with	gene	0.50
GFAP	associated_with	gene	0.50
CD44	associated_with	gene	0.50
PRDX6	associated_with	gene	0.50
MAPK1	associated_with	gene	0.50
NOS1	associated_with	gene	0.50
Sod1	associated_with	gene	0.50
MMP1	associated_with	gene	0.50
HSPB1	associated_with	gene	0.50
CRYAB	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.934

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06