gene

E2F5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about E2F5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

10Outgoing

11Incoming

0Experiments

Summary

E2F Transcription Factor 5 - a cell cycle regulator with roles in neuronal differentiation and neurodegeneration

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🧬 Gene Info

Gene Symbol	E2F5
Full Name	E2F Transcription Factor 5
Chromosome	8q21.3
Protein Family	E2F transcription factor family
Protein Type	Transcription factor, Cell cycle regulator
Function	encodes E2F Transcription Factor 5, a member of the E2F family of transcription factors that play critical roles in regulating cell cycle progression, cellular differentiation, and apoptosis
Primary Expression	a tissue-specific manner and has been shown to function primarily as a transcriptional repressor in differentiated cells
Exons	7
UniProt ID	Q504Y5
NCBI Gene ID	1883
Ensembl ID	ENSG00000158636
OMIM	600223
GeneCards	E2F5
Human Protein Atlas	E2F5
Encoded Protein	E2F transcription factor 5
Associated Diseases	Cancer, Carcinoma, Ms, Tumor
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: E2F5 — AlphaFold Q504Y5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    E2F5["<b>E2F5</b>"]
    Carcinoma{"Carcinoma"}
    E2F5 -->|"associated with"| Carcinoma
    Ms{"Ms"}
    E2F5 -->|"associated with"| Ms
    Cancer{"Cancer"}
    E2F5 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    E2F5 -->|"associated with"| Tumor
    CDKN2B["CDKN2B"]
    E2F5 -->|"associated with"| CDKN2B
    TGFBR1["TGFBR1"]
    E2F5 -->|"associated with"| TGFBR1
    CANCER["CANCER"]
    E2F5 -->|"associated with"| CANCER
    BMP2["BMP2"]
    E2F5 -->|"associated with"| BMP2
    TGFB2["TGFB2"]
    E2F5 -->|"associated with"| TGFB2
    BMP7["BMP7"]
    E2F5 -->|"associated with"| BMP7
    neurodegeneration["neurodegeneration"]
    E2F5 -->|"implicated in"| neurodegeneration
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| E2F5
    BMP4["BMP4"]
    BMP4 -->|"associated with"| E2F5
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| E2F5
    MYC["MYC"]
    MYC -->|"associated with"| E2F5
    style E2F5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Carcinoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
CDKN2B	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
BMP2	associated_with	gene	0.60
TGFB2	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
CANCER	associated_with	gene	0.60

Incoming (11)

Source	Relation	Type	Str
TGFBR2	associated_with	gene	0.60
BMP4	associated_with	gene	0.60
MYC	associated_with	gene	0.60
BMP2	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
TGFB2	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CANCER	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found