Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TGFBR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TGFBR2 |
| Full Name | Transforming Growth Factor Beta Receptor 2 |
| Chromosome | 3p22.1 |
| Function | TGFBR2 (Transforming Growth Factor Beta Receptor 2) encodes the type II TGF-β receptor, a transmembrane serine/threonine kinase that is essential for TGF-β signaling. |
| Primary Expression | the brain: |
| Pathways | TGF-β, TGF-β signaling, PI3K, MAPK |
| UniProt ID | [P37173](https://www.uniprot.org/uniprot/P37173) |
| Ensembl ID | ENSG00000163513 |
| GeneCards | TGFBR2 |
| Human Protein Atlas | TGFBR2 |
| Neuronal survival | Anti-apoptotic signaling through multiple pathways |
| Neuroinflammation | Suppression of microglial activation |
| Synaptic plasticity | Regulation of dendritic spine formation |
| Astrocyte function | Modulation of astrocytic responses |
| Oligodendrocyte maturation | Promotes myelination |
| Associated Diseases | Als, Cancer, Carcinoma, Colorectal Cancer, Gastric Cancer |
| Interactions | PIEZO1, AND, GENES, SMAD2, TGFBR1, TGF |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TGFBR2["<b>TGFBR2</b>"]
Cardiovascular{"Cardiovascular"}
TGFBR2 -->|"activates"| Cardiovascular
Inflammation{"Inflammation"}
TGFBR2 -->|"activates"| Inflammation
Ms{"Ms"}
TGFBR2 -->|"activates"| Ms
Carcinoma{"Carcinoma"}
TGFBR2 -->|"associated with"| Carcinoma
Cancer{"Cancer"}
TGFBR2 -->|"associated with"| Cancer
Tumor{"Tumor"}
TGFBR2 -->|"activates"| Tumor
TGFBR2 -->|"regulates"| Tumor
PIEZO1["PIEZO1"]
TGFBR2 -->|"inhibits"| PIEZO1
Endocytosis(["Endocytosis"])
TGFBR2 -->|"activates"| Endocytosis
Autophagy(["Autophagy"])
TGFBR2 -->|"activates"| Autophagy
Tgf__(["Tgf-Beta"])
TGFBR2 -->|"inhibits"| Tgf__
BMP4["BMP4"]
TGFBR2 -->|"associated with"| BMP4
TGFB1["TGFB1"]
TGFB1 -->|"associated with"| TGFBR2
style TGFBR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Cancer | associated_with | disease | 0.75 |
| CANCER | associated_with | gene | 0.70 |
| Cardiovascular | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Infection | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| Colorectal Cancer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Gastric Cancer | associated_with | disease | 0.65 |
| PIEZO1 | inhibits | gene | 0.60 |
| BMP4 | associated_with | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| E2F5 | associated_with | gene | 0.60 |
| CDKN2B | associated_with | gene | 0.60 |
| TGFBR1 | associated_with | gene | 0.60 |
| BMP2 | associated_with | gene | 0.60 |
| TGFB2 | associated_with | gene | 0.60 |
| BMP7 | associated_with | gene | 0.60 |
| GATA3 | regulates | gene | 0.60 |
| STAT3 | expressed_in | gene | 0.60 |
| SMAD3 | expressed_in | gene | 0.60 |
| TGFBR1 | expressed_in | gene | 0.60 |
| TGFB1 | expressed_in | gene | 0.60 |
| ARID1A | regulates | gene | 0.60 |
| ACVR2A | regulates | gene | 0.60 |
| MRE11 | associated_with | gene | 0.60 |
| MSH2 | associated_with | gene | 0.60 |
| MSH3 | regulates | gene | 0.60 |
| MLH1 | associated_with | gene | 0.60 |
| MSH6 | regulates | gene | 0.60 |
| HDAC2 | regulates | gene | 0.60 |
| PMS2 | associated_with | gene | 0.60 |
| TREM2 | regulates | gene | 0.60 |
| Endocytosis | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Tgf-Β | inhibits | pathway | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| CLDN4 | associated_with | gene | 0.60 |
| CDH1 | regulates | gene | 0.60 |
| ERBB3 | associated_with | gene | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| TGFB1 | associated_with | gene | 0.60 |
| BAX | regulates | gene | 0.60 |
| BRAF | associated_with | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| MS4A | regulates | gene | 0.60 |
| SMAD2 | activates | gene | 0.55 |
| TGFBR1 | activates | gene | 0.55 |
| TGF | activates | gene | 0.55 |
| benchmark_ot_ad_answer_key:TGFBR2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity