Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDKN2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CDKN2B is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Aging, Cancer, Carcinoma. Connected to 23 entities in the SciDEX knowledge graph.
| Gene Symbol | CDKN2B |
| Full Name | Cyclin-Dependent Kinase Inhibitor 2B (p15/INK4b) |
| Chromosome | 9p21.3 |
| Protein Type | Kinase |
| Function | p15 binds to and inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), which are required for G1 phase progression. |
| Pathways | TGF-β, TGF-β signaling |
| UniProt ID | [P42772](https://www.uniprot.org/uniprot/P42772) |
| Ensembl ID | ENSG00000147883 |
| OMIM | 600431 |
| GeneCards | CDKN2B |
| Human Protein Atlas | CDKN2B |
| Associated Diseases | Cancer, Carcinoma, Ms, Senescence, Tumor |
| Interactions | MYC, CYCLIN D1, RNA, AND, LNCRNA, CANCER |
| KG Connections | 62 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CDKN2B["<b>CDKN2B</b>"]
Carcinoma{"Carcinoma"}
CDKN2B -->|"associated with"| Carcinoma
Ms{"Ms"}
CDKN2B -->|"associated with"| Ms
Cancer{"Cancer"}
CDKN2B -->|"associated with"| Cancer
Tumor{"Tumor"}
CDKN2B -->|"associated with"| Tumor
TGFBR1["TGFBR1"]
CDKN2B -->|"associated with"| TGFBR1
CANCER["CANCER"]
CDKN2B -->|"associated with"| CANCER
BMP2["BMP2"]
CDKN2B -->|"associated with"| BMP2
TGFB2["TGFB2"]
CDKN2B -->|"associated with"| TGFB2
BMP7["BMP7"]
CDKN2B -->|"associated with"| BMP7
neurodegeneration["neurodegeneration"]
CDKN2B -->|"implicated in"| neurodegeneration
TGFBR2["TGFBR2"]
TGFBR2 -->|"associated with"| CDKN2B
BMP4["BMP4"]
BMP4 -->|"associated with"| CDKN2B
MIRNAS["MIRNAS"]
MIRNAS -->|"associated with"| CDKN2B
MYC["MYC"]
MYC -->|"associated with"| CDKN2B
E2F5["E2F5"]
E2F5 -->|"associated with"| CDKN2B
style CDKN2B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| cardiomyocyte degeneration | promotes | phenotype | 0.85 |
| Tumor | risk_factor_for | disease | 0.85 |
| Carcinoma | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Senescence | associated_with | disease | 0.65 |
| Cardiac | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| TGFBR1 | associated_with | gene | 0.60 |
| BMP2 | associated_with | gene | 0.60 |
| TGFB2 | associated_with | gene | 0.60 |
| BMP7 | associated_with | gene | 0.60 |
| NRAS | associated_with | gene | 0.60 |
| PLCG1 | associated_with | gene | 0.60 |
| TET2 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| U2AF1 | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| Stem Cell | associated_with | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| LNCRNA | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| ENDOG | co_discussed | protein | 0.50 |
| MYC | activates | gene | 0.50 |
| UBIQUITIN | co_discussed | protein | 0.50 |
| NRAS | co_expressed_with | gene | 0.50 |
| CYCLIN D1 | activates | gene | 0.50 |
| RNA | activates | gene | 0.50 |
| EIF4E | co_expressed_with | protein | 0.50 |
| benchmark_ot_ad_answer_key:CDKN2B | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| STAT3 | activates | protein | 0.90 |
| TGFBR2 | associated_with | gene | 0.60 |
| BMP4 | associated_with | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| E2F5 | associated_with | gene | 0.60 |
| STAT3 | therapeutic_target | gene | 0.60 |
| SIRT2 | therapeutic_target | gene | 0.60 |
| BMP2 | associated_with | gene | 0.60 |
| TGFBR1 | associated_with | gene | 0.60 |
| BMP7 | associated_with | gene | 0.60 |
| TGFB2 | associated_with | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| CDK6 | associated_with | gene | 0.60 |
| CDKN2A | associated_with | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| C-MYC | activates | gene | 0.60 |
| CDKN2B-AS1 | activates | gene | 0.60 |
| CDK6 | co_expressed_with | gene | 0.50 |
| CDKN2A | co_expressed_with | gene | 0.50 |
| CANCER | co_discussed | gene | 0.50 |
| benchmark_ot_ad_answer_key:CDKN2B | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||