gene

CDKN2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections
0Hypotheses
0Analyses
35Outgoing
27Incoming

Summary

CDKN2B is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Aging, Cancer, Carcinoma. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCDKN2B
Full NameCyclin-Dependent Kinase Inhibitor 2B (p15/INK4b)
Chromosome9p21.3
Protein TypeKinase
Functionp15 binds to and inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), which are required for G1 phase progression.
PathwaysTGF-β, TGF-β signaling
UniProt ID[P42772](https://www.uniprot.org/uniprot/P42772)
Ensembl IDENSG00000147883
OMIM600431
GeneCardsCDKN2B
Human Protein AtlasCDKN2B
Associated DiseasesCancer, Carcinoma, Ms, Senescence, Tumor
InteractionsMYC, CYCLIN D1, RNA, AND, LNCRNA, CANCER
KG Connections62 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

CDKN2B

gene · 972 words

Cellular Senescence in Neurodegeneration

mechanism · 3260 words

PRDM4 Gene

gene · 2143 words

E2F5 Gene

gene · 1671 words

TGFB2 Gene

gene · 990 words

MECOM Gene

gene · 669 words

Pathway Diagram

graph TD
    CDKN2B["<b>CDKN2B</b>"]
    Carcinoma{"Carcinoma"}
    CDKN2B -->|"associated with"| Carcinoma
    Ms{"Ms"}
    CDKN2B -->|"associated with"| Ms
    Cancer{"Cancer"}
    CDKN2B -->|"associated with"| Cancer
    Tumor{"Tumor"}
    CDKN2B -->|"associated with"| Tumor
    TGFBR1["TGFBR1"]
    CDKN2B -->|"associated with"| TGFBR1
    CANCER["CANCER"]
    CDKN2B -->|"associated with"| CANCER
    BMP2["BMP2"]
    CDKN2B -->|"associated with"| BMP2
    TGFB2["TGFB2"]
    CDKN2B -->|"associated with"| TGFB2
    BMP7["BMP7"]
    CDKN2B -->|"associated with"| BMP7
    neurodegeneration["neurodegeneration"]
    CDKN2B -->|"implicated in"| neurodegeneration
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| CDKN2B
    BMP4["BMP4"]
    BMP4 -->|"associated with"| CDKN2B
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| CDKN2B
    MYC["MYC"]
    MYC -->|"associated with"| CDKN2B
    E2F5["E2F5"]
    E2F5 -->|"associated with"| CDKN2B
    style CDKN2B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
cardiomyocyte degenerationpromotesphenotype0.85
Tumorrisk_factor_fordisease0.85
Carcinomaassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (27)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
STAT3activatesprotein0.90
TGFBR2associated_withgene0.60
BMP4associated_withgene0.60
MYCassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found