gene

BMP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

1Hypotheses

1Analyses

32Outgoing

13Incoming

Summary

TGF-beta superfamily member critical for neural development and neurodegeneration

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🧬 Gene Info

Gene Symbol	BMP4
Function	encodes a member of the TGF-beta superfamily of signaling molecules.
Molecular Weight	47 kDa
Amino Acids	116 aa
Pathways	MAPK Pathway, PI3K, TGF-β
Ensembl ID	ENSG00000109475
GeneCards	BMP4
Human Protein Atlas	BMP4
Associated Diseases	ALZHEIMER'S DISEASE, Cancer, Carcinoma, Ms, Tumor
Interactions	TGFBR1, TGFB2, BMP7, TREM2, HEDGEHOG, APOE4
KG Connections	45 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: BMP4 — PDB 1M4U Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BMP4["<b>BMP4</b>"]
    Carcinoma{"Carcinoma"}
    BMP4 -->|"associated with"| Carcinoma
    Ms{"Ms"}
    BMP4 -->|"associated with"| Ms
    Cancer{"Cancer"}
    BMP4 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    BMP4 -->|"associated with"| Tumor
    MIRNAS["MIRNAS"]
    BMP4 -->|"associated with"| MIRNAS
    MYC["MYC"]
    BMP4 -->|"associated with"| MYC
    E2F5["E2F5"]
    BMP4 -->|"associated with"| E2F5
    CDKN2B["CDKN2B"]
    BMP4 -->|"associated with"| CDKN2B
    TGFBR1["TGFBR1"]
    BMP4 -->|"activates"| TGFBR1
    CANCER["CANCER"]
    BMP4 -->|"associated with"| CANCER
    BMP2["BMP2"]
    BMP4 -->|"associated with"| BMP2
    TGFB2["TGFB2"]
    BMP4 -->|"activates"| TGFB2
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| BMP4
    style BMP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
TREM2	regulates	gene	0.70
TREM2	activates	gene	0.70
ALZHEIMER'S DISEASE	protects_against	disease	0.70
ALZHEIMER'S DISEASE	treats	disease	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
OLIGODENDROCYTE	produces	cell_type	0.70
MICROGLIA	inhibits	cell_type	0.70
MICROGLIA	causes	cell_type	0.70
Carcinoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
white matter damage	causes (pericyte-derived BMP4 causes white matter damage a)	mechanism	0.65
MYC	associated_with	gene	0.60
E2F5	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
TGFBR1	activates	gene	0.60
BMP2	associated_with	gene	0.60
TGFB2	activates	gene	0.60
BMP7	activates	gene	0.60
Tgf-Beta	interacts_with	pathway	0.60
SHH	regulates	gene	0.60
MIRNAS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
HEDGEHOG	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
Fibroblast	activates	cell_type	0.60
Collagen	therapeutic_target	protein	0.60
astrocytes	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
oligodendrocyte_dysfunction	causes	pathological_process	0.50

Incoming (13)

Source	Relation	Type	Str
BMPR1B	participates_in	gene	0.80
MICROGLIA	regulates	cell_type	0.70
TGFBR2	associated_with	gene	0.60
BMP2	associated_with	gene	0.60
MYC	associated_with	gene	0.60
P4HB	therapeutic_target	gene	0.60
APOE4	phosphorylates	gene	0.60
APOE4	activates	gene	0.60
AND	activates	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.50
ALZHEIMER	associated_with	disease	0.50
h-e064f134	targets	hypothesis	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
ANGPTL4 regulates the adipogenic-osteogenic differentiation balance of bone marr [PMID:41482017]	Huang F, Zhu Z, Xing Q, Li M	Biochimie	2026	0
BMP4 dose dictates lineage specification bias in human periodontal ligament stem [PMID:41568233]	Li Y, Tang Q, Li L, Lin C, Guo M et al.	Front Bioeng Biotechnol	2025	0

BMP4

Understanding Entity Pages

Summary

Wiki Pages (21)

BMP4 Gene (Bone Morphogenetic Protein 4)

neurovascular-dysfunction

GLI1 — GLI Family Zinc Finger 1

BMPR2 Gene

SMAD5 — SMAD Family Member 5

iPSC-Derived Microglia

BMPR1A — Bone Morphogenetic Protein Receptor Type 1A

Adult Hippocampal Neurogenesis: Impaired in Alzheimer's Disease, Enhanced in Superagers

Blood-Brain Barrier Dysfunction Pathway

SMAD5 Protein

SMAD9 — SMAD Family Member 9

Blood-Brain Barrier and Neuroimmune Interface in CBS/PSP

E2F5 Gene

TGF-β/BMP Signaling Pathway in Neurodegeneration

BMP4 Protein

BMPR1A (ALK3) Protein

PD TGF-beta/BMP Signaling Companies

BMP7 Gene (Bone Morphogenetic Protein 7)

NOG Gene

DLX5 Protein