Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FGF5 is a gene implicated in neurodegeneration research. Key relationships include: protects against, interacts with, implicated in. Associated with Carcinoma, Ms. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | FGF5 |
| Full Name | Fibroblast Growth Factor 5 |
| Aliases | HBGF-5, TCMGLY, Smag-82, Zigzag [@fgf2019] |
| Chromosome | 4q21.21 (GRCh38: 80266588..80291017) |
| Protein Type | Gene |
| Function | FGF5 has diverse biological functions |
| Primary Expression | astrocytes and may influence astrocyte function |
| Molecular Weight | ~29 kDa |
| Amino Acids | 267 aa |
| UniProt ID | P12034 |
| NCBI Gene ID | 2250 |
| Ensembl ID | ENSG00000138640 |
| GeneCards | FGF5 |
| Human Protein Atlas | FGF5 |
| Associated Diseases | neurodegeneration |
| Interactions | IL1A |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FGF5["<b>FGF5</b>"]
Ms{"Ms"}
FGF5 -->|"interacts with"| Ms
Carcinoma{"Carcinoma"}
FGF5 -->|"interacts with"| Carcinoma
IL1A["IL1A"]
FGF5 -->|"interacts with"| IL1A
XBP1["XBP1"]
FGF5 -->|"protects against"| XBP1
DNAJB9["DNAJB9"]
FGF5 -->|"protects against"| DNAJB9
FN1["FN1"]
FGF5 -->|"protects against"| FN1
ERN1["ERN1"]
FGF5 -->|"protects against"| ERN1
PDIA6["PDIA6"]
FGF5 -->|"protects against"| PDIA6
Unfolded_Protein_Response(["Unfolded Protein Response"])
FGF5 -->|"interacts with"| Unfolded_Protein_Response
neurodegeneration["neurodegeneration"]
FGF5 -->|"implicated in"| neurodegeneration
PECAM1["PECAM1"]
PECAM1 -->|"protects against"| FGF5
FOS["FOS"]
FOS -->|"protects against"| FGF5
FGF1["FGF1"]
FGF1 -->|"protects against"| FGF5
style FGF5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | interacts_with | disease | 0.65 |
| Carcinoma | interacts_with | disease | 0.65 |
| IL1A | interacts_with | gene | 0.60 |
| XBP1 | protects_against | gene | 0.60 |
| DNAJB9 | protects_against | gene | 0.60 |
| ERN1 | protects_against | gene | 0.60 |
| PDIA6 | protects_against | gene | 0.60 |
| FN1 | protects_against | gene | 0.60 |
| Unfolded Protein Response | interacts_with | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||