gene

FGF5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections
0Hypotheses
0Analyses
9Outgoing
3Incoming

Summary

FGF5 is a gene implicated in neurodegeneration research. Key relationships include: protects against, interacts with, implicated in. Associated with Carcinoma, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolFGF5
Full NameFibroblast Growth Factor 5
AliasesHBGF-5, TCMGLY, Smag-82, Zigzag [@fgf2019]
Chromosome4q21.21 (GRCh38: 80266588..80291017)
Protein TypeGene
FunctionFGF5 has diverse biological functions
Primary Expressionastrocytes and may influence astrocyte function
Molecular Weight~29 kDa
Amino Acids267 aa
UniProt IDP12034
NCBI Gene ID2250
Ensembl IDENSG00000138640
GeneCardsFGF5
Human Protein AtlasFGF5
Associated Diseasesneurodegeneration
InteractionsIL1A
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: FGF5 — AlphaFold P12034 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Fibroblast Growth Factor 5

gene · 566 words

FGF10 — Fibroblast Growth Factor 10

gene · 3796 words

FGF Signaling in Parkinson's Disease

mechanism · 2485 words

Fibroblast Growth Factor Signaling in Neurodegeneration

mechanism · 1987 words

FGF4 — Fibroblast Growth Factor 4

gene · 1668 words

FGF1 Gene

gene · 672 words

Pathway Diagram

graph TD
    FGF5["<b>FGF5</b>"]
    Ms{"Ms"}
    FGF5 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    FGF5 -->|"interacts with"| Carcinoma
    IL1A["IL1A"]
    FGF5 -->|"interacts with"| IL1A
    XBP1["XBP1"]
    FGF5 -->|"protects against"| XBP1
    DNAJB9["DNAJB9"]
    FGF5 -->|"protects against"| DNAJB9
    FN1["FN1"]
    FGF5 -->|"protects against"| FN1
    ERN1["ERN1"]
    FGF5 -->|"protects against"| ERN1
    PDIA6["PDIA6"]
    FGF5 -->|"protects against"| PDIA6
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    FGF5 -->|"interacts with"| Unfolded_Protein_Response
    neurodegeneration["neurodegeneration"]
    FGF5 -->|"implicated in"| neurodegeneration
    PECAM1["PECAM1"]
    PECAM1 -->|"protects against"| FGF5
    FOS["FOS"]
    FOS -->|"protects against"| FGF5
    FGF1["FGF1"]
    FGF1 -->|"protects against"| FGF5
    style FGF5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

TargetRelationTypeStr
Msinteracts_withdisease0.65
Carcinomainteracts_withdisease0.65
IL1Ainteracts_withgene0.60
XBP1protects_againstgene0.60
DNAJB9protects_againstgene0.60

Incoming (3)

SourceRelationTypeStr
PECAM1protects_againstgene0.60
FOSprotects_againstgene0.60
FGF1protects_againstgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found