protein

FN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

364Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

FN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Aging, Als. Connected to 248 entities in the SciDEX knowledge graph.

View on Wiki →

🔬 Protein Info

Gene Symbol	FN1
Function	Fibronectin (FN1) is a high-molecular-weight extracellular matrix glycoprotein that plays crucial roles in cell adhesion, migration, and tissue morphogenesis.
Primary Expression	Hippocampus
Pathways	Akt, Pi3K, Angiogenesis, Epigenetic, Immune Response
GeneCards	FN1
Human Protein Atlas	FN1
Associated Diseases	ALS, Aging, Carcinoma, Diabetes, Fibrosis
Interactions	MTOR, PI3K, UBC, ATP5A1, SOD1, EGFR
KG Connections	364 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FN1["FN1"]
    FN1 -.protects against.-> APOE4["APOE4"]
    FN1 -->|"component_of"| blood_brain_barrier["blood-brain barrier"]
    FN1 -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    FN1 -->|"causes"| gliosis["gliosis"]
    FN1 -->|"target for"| Glioblastoma["Glioblastoma"]
    FN1 -->|"target for"| Als["Als"]
    FN1 -->|"regulates"| Tumor["Tumor"]
    FN1 -->|"target for"| Ms["Ms"]
    APOE4 -->|"contributes to"| FN1
    ANXA2["ANXA2"] -->|"regulates"| FN1
    PI3K["PI3K"] -->|"target for"| FN1
    AKT["AKT"] -->|"activates"| FN1
    AGING["AGING"] -.protects against.-> FN1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -.protects against.-> FN1
    CEBPD["CEBPD"] -->|"activates"| FN1
    EGFR["EGFR"] -->|"activates"| FN1
    GBM["GBM"] -->|"regulates"| FN1

Outgoing (240)

Target	Relation	Type	Str
APOE4	protects_against	gene	0.90
blood-brain barrier	component_of	phenotype	0.90
Als	activates	disease	0.85
Alzheimer's disease	protects_against	disease	0.80
gliosis	causes	phenotype	0.80
Glioblastoma Invasion	modulates	phenotype	0.80
Glioblastoma	activates	disease	0.75
Als	inhibits	disease	0.75
blood-brain barrier integrity	associated_with	process	0.75
GBM	regulates	gene	0.70
Angiogenesis	activates	pathway	0.70
GLIOBLASTOMA	activates	gene	0.70
GENES	activates	gene	0.70
Glioblastoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	protects_against	disease	0.65
Aging	protects_against	disease	0.65
Als	protects_against	disease	0.65
Ms	associated_with	disease	0.65
Dementia	protects_against	disease	0.65
Ms	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Carcinoma	interacts_with	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	regulates	disease	0.65
Ms	contributes_to	disease	0.65
Aging	associated_with	disease	0.65
Fibrosis	expressed_in	disease	0.65
ALS	activates	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Diabetes	activates	disease	0.65

Incoming (124)

Source	Relation	Type	Str
APOE4	contributes_to	gene	0.80
ANXA2	regulates	gene	0.60
PI3K	therapeutic_target	gene	0.60
SQSTM1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ATG	associated_with	gene	0.60
AKT	activates	gene	0.60
AGING	protects_against	gene	0.60
FN1B	associated_with	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
CEBPD	activates	gene	0.60
PI3K	activates	gene	0.60
EGFR	activates	gene	0.60
GBM	regulates	gene	0.60
FYN	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
VCP	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
EGFR	interacts_with	gene	0.60
HSP90AA1	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
HSP90AB1	expressed_in	gene	0.60
MDM2	interacts_with	gene	0.60
HSF1	expressed_in	gene	0.60
GRB2	interacts_with	gene	0.60
MMP9	associated_with	gene	0.60
PI3K	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
C1Q	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
CCT2	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
SOX2	interacts_with	gene	0.60
YWHAZ	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FN1

Understanding Entity Pages

Summary

Wiki Pages (14)

Meningeal Fibroblasts

Pial Cells

Extracellular Matrix and Integrin Modulator Therapy for Neurodegeneration

RIPK1 (Receptor-Interacting Kinase 1)

CHL1 Protein

Radial Glia

JARID2

NFASC — Neurofascin

IL5 Gene

L1CAM (L1 Cell Adhesion Molecule)

FN1 Protein (Fibronectin)

Fibroblast Growth Factor 5