Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDIA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PDIA6 (ERP29/P5) is an ER-resident chaperone involved in protein folding, unfolded protein response, and neurodegenerative disease through ER stress modulation.
| Gene Symbol | PDIA6 |
| Full Name | Protein Disulfide Isomerase Family A Member 6 |
| Aliases | ERP29/P5 |
| Chromosome | 2p25.1 |
| Protein Type | Isomerase |
| Function | PDIA6 functions as a chaperone and assists in protein folding in the endoplasmic reticulum. |
| Primary Expression | most tissues with high expression in brain, lung, and pancreas |
| Molecular Weight | 48 kDa |
| Pathways | Apoptosis, apoptosis, apoptosis pathway |
| UniProt ID | [Q15020](https://www.uniprot.org/uniprot/Q15020) |
| Ensembl ID | ENSG00000143870 |
| GeneCards | PDIA6 |
| Human Protein Atlas | PDIA6 |
| PDI (PDIA1) | Canonical protein disulfide isomerase and PDIA6 family prototype |
| GRP78/BiP | ER chaperone and PDIA6 interaction partner |
| Associated Diseases | neurodegeneration |
| Interactions | SLC16A1, APOPTOSIS, AND, Insulin, IL1A |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PDIA6["<b>PDIA6</b>"]
Ms{"Ms"}
PDIA6 -->|"interacts with"| Ms
Carcinoma{"Carcinoma"}
PDIA6 -->|"interacts with"| Carcinoma
Unfolded_Protein_Response(["Unfolded Protein Response"])
PDIA6 -->|"interacts with"| Unfolded_Protein_Response
neurodegeneration["neurodegeneration"]
PDIA6 -->|"implicated in"| neurodegeneration
PECAM1["PECAM1"]
PECAM1 -->|"protects against"| PDIA6
FOS["FOS"]
FOS -->|"protects against"| PDIA6
FGF1["FGF1"]
FGF1 -->|"protects against"| PDIA6
FGF5["FGF5"]
FGF5 -->|"protects against"| PDIA6
IL1A["IL1A"]
IL1A -->|"interacts with"| PDIA6
XBP1["XBP1"]
XBP1 -->|"protects against"| PDIA6
DNAJB9["DNAJB9"]
DNAJB9 -->|"protects against"| PDIA6
FN1["FN1"]
FN1 -->|"protects against"| PDIA6
ERN1["ERN1"]
ERN1 -->|"protects against"| PDIA6
style PDIA6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | interacts_with | disease | 0.65 |
| Carcinoma | interacts_with | disease | 0.65 |
| Diabetes | expressed_in | disease | 0.65 |
| SLC16A1 | activates | gene | 0.60 |
| SLC16A1 | biomarker_for | gene | 0.60 |
| Unfolded Protein Response | interacts_with | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| GENES | biomarker_for | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| DIABETES MELLITUS | expressed_in | gene | 0.60 |
| Insulin | activates | protein | 0.60 |
| App | expressed_in | protein | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| SLC16A1 | associated_with | gene | 0.50 |
| apoptosis | activates | process | 0.50 |
| INSULIN | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PECAM1 | protects_against | gene | 0.60 |
| FOS | protects_against | gene | 0.60 |
| FGF1 | protects_against | gene | 0.60 |
| FGF5 | protects_against | gene | 0.60 |
| IL1A | interacts_with | gene | 0.60 |
| XBP1 | protects_against | gene | 0.60 |
| DNAJB9 | protects_against | gene | 0.60 |
| ERN1 | protects_against | gene | 0.60 |
| SLC16A1 | activates | gene | 0.60 |
| FN1 | protects_against | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||