gene

pecam1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about pecam1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

47Outgoing

25Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	PECAM1
Full Name	Platelet Endothelial Cell Adhesion Molecule 1
Chromosome	17q23
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	72 kDa
Amino Acids	738 aa
UniProt ID	P16284
NCBI Gene ID	5175
Ensembl ID	ENSG00000261371
GeneCards	PECAM1
Human Protein Atlas	PECAM1
Associated Diseases	Cancer, Als, Myocardial Infarction, Coronary Artery Disease, Atherosclerosis, Inflammation
Databases	GeneCards HPA STRING

🔮 Predicted Structure: pecam1 — AlphaFold P16284 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PECAM1["PECAM1"]
    PECAM1 -->|"interacts"| Ms["Ms"]
    PECAM1 -->|"interacts"| Carcinoma["Carcinoma"]
    PECAM1 -->|"expressed in"| Als["Als"]
    PECAM1 -->|"expressed in"| Tumor["Tumor"]
    PECAM1 -.protects against.-> FOS["FOS"]
    PECAM1 -.protects against.-> FGF1["FGF1"]
    PECAM1 -.protects against.-> FGF5["FGF5"]
    PECAM1 -->|"interacts"| IL1A["IL1A"]

Outgoing (47)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
oxidative stress response	participates_in	pathway	0.70
Ms	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Myocardial Infarction	associated_with	disease	0.65
Coronary Artery Disease	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
FOS	protects_against	gene	0.60
FGF1	protects_against	gene	0.60
FGF5	protects_against	gene	0.60
IL1A	interacts_with	gene	0.60
XBP1	protects_against	gene	0.60
DNAJB9	protects_against	gene	0.60
ERN1	protects_against	gene	0.60
PDIA6	protects_against	gene	0.60
IL6	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
FOS	associated_with	gene	0.60
PI3K	expressed_in	gene	0.60
CAV1	associated_with	gene	0.60
AKT	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
PTGER2	activates	gene	0.60
THBS1	activates	gene	0.60
RORC	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
TNF	regulates	gene	0.60
VIM	regulates	gene	0.60
FN1	protects_against	gene	0.60
Unfolded Protein Response	interacts_with	pathway	0.60
P53	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60
Akt	expressed_in	pathway	0.60
Pi3K	expressed_in	pathway	0.60
LDL	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
T cells	expressed_in	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
benchmark_ot_ad_answer_key:PECAM1	data_in	dataset_row	0.00

Incoming (25)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
T CELLS	activates	cell_type	0.65
T CELLS	regulates	cell_type	0.65
CD14	associated_with	gene	0.60
CD36	activates	gene	0.60
CD38	activates	gene	0.60
CD4	activates	gene	0.60
MS4A6A	activates	gene	0.60
ACTB	regulates	gene	0.60
BECN1	regulates	gene	0.60
CD31	regulates	gene	0.60
CKB	regulates	gene	0.60
CTS	regulates	gene	0.60
GAPDH	regulates	gene	0.60
GATA3	regulates	gene	0.60
GLB1	regulates	gene	0.60
IL1RL1	regulates	gene	0.60
IL4	regulates	gene	0.60
IL7R	regulates	gene	0.60
LC3	regulates	gene	0.60
LDH	regulates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ANXA5	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
benchmark_ot_ad_answer_key:PECAM1	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

pecam1

Understanding Entity Pages

Wiki Pages (16)

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ICAM1 Protein

Olink Proteomics

Brain Vascular Endothelial Cells

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Fibroblast Growth Factor 5

Integrin Beta-1 (ITGB1) Protein