Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJB9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DNAJB9 is a gene implicated in neurodegeneration research. Key relationships include: protects against, associated with, interacts with. Associated with ALS, Aging, Als. Connected to 21 entities in the SciDEX knowledge graph.
| Gene Symbol | DNAJB9 |
| Full Name | DnaJ heat shock protein family (Hsp40) member B9 |
| Chromosome | 9p24.1 |
| Function | is a member of the DnaJ heat shock protein family, which functions as a co-chaperone in the endoplasmic reticulum (ER). |
| Subcellular Localization | DNAJB9 is exclusively localized to the ER lumen, where it performs its chaperone functions. Its retention is mediated by |
| Molecular Weight | 27 kDa |
| Amino Acids | 292 aa |
| Exons | 5 |
| UniProt ID | [Q9Y3X0](https://www.uniprot.org/uniprot/Q9Y3X0) |
| Ensembl ID | ENSG00000102948 |
| GeneCards | DNAJB9 |
| Human Protein Atlas | DNAJB9 |
| J domain function | Stimulates BiP ATPase activity |
| Substrate binding | Delivers folded/unfolding proteins to BiP |
| Allosteric regulation | Modulates BiP substrate affinity |
| Associated Diseases | ALS, Aging |
| Interactions | Proteins, IL1A, HSPA1A |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJB9["<b>DNAJB9</b>"]
Aging{"Aging"}
DNAJB9 -->|"associated with"| Aging
Als{"Als"}
DNAJB9 -->|"associated with"| Als
Ms{"Ms"}
DNAJB9 -->|"interacts with"| Ms
Carcinoma{"Carcinoma"}
DNAJB9 -->|"interacts with"| Carcinoma
ALS{"ALS"}
DNAJB9 -->|"associated with"| ALS
Nf__b(["Nf-Kappab"])
DNAJB9 -->|"associated with"| Nf__b
HSPA1A["HSPA1A"]
DNAJB9 -->|"associated with"| HSPA1A
FN1["FN1"]
DNAJB9 -->|"protects against"| FN1
ERN1["ERN1"]
DNAJB9 -->|"protects against"| ERN1
PDIA6["PDIA6"]
DNAJB9 -->|"protects against"| PDIA6
Unfolded_Protein_Response(["Unfolded Protein Response"])
DNAJB9 -->|"interacts with"| Unfolded_Protein_Response
AGING["AGING"]
DNAJB9 -->|"associated with"| AGING
HSPA1A -->|"associated with"| DNAJB9
PECAM1["PECAM1"]
PECAM1 -->|"protects against"| DNAJB9
FOS["FOS"]
FOS -->|"protects against"| DNAJB9
FGF1["FGF1"]
FGF1 -->|"protects against"| DNAJB9
FGF5["FGF5"]
FGF5 -->|"protects against"| DNAJB9
IL1A["IL1A"]
IL1A -->|"interacts with"| DNAJB9
XBP1["XBP1"]
XBP1 -->|"protects against"| DNAJB9
AND["AND"]
AND -->|"associated with"| DNAJB9
AGING -->|"associated with"| DNAJB9
style DNAJB9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Age-Related Diseases | biomarker_for | disease | 0.85 |
| Aging | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Carcinoma | interacts_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| HSPA1A | associated_with | gene | 0.60 |
| ERN1 | protects_against | gene | 0.60 |
| PDIA6 | protects_against | gene | 0.60 |
| HSPA1A | upregulates | entity | 0.60 |
| HSPA1A | regulates | gene | 0.60 |
| Nf-Κb | associated_with | pathway | 0.60 |
| FN1 | protects_against | gene | 0.60 |
| Unfolded Protein Response | interacts_with | pathway | 0.60 |
| AGING | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| Interleukin | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| Proteins | activates | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSPA1A | associated_with | gene | 0.60 |
| PECAM1 | protects_against | gene | 0.60 |
| FOS | protects_against | gene | 0.60 |
| FGF1 | protects_against | gene | 0.60 |
| FGF5 | protects_against | gene | 0.60 |
| IL1A | interacts_with | gene | 0.60 |
| XBP1 | protects_against | gene | 0.60 |
| BGN | regulates | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| HSPA1A | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||