gene

DNAJB9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJB9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
0Hypotheses
0Analyses
19Outgoing
11Incoming

Summary

DNAJB9 is a gene implicated in neurodegeneration research. Key relationships include: protects against, associated with, interacts with. Associated with ALS, Aging, Als. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDNAJB9
Full NameDnaJ heat shock protein family (Hsp40) member B9
Chromosome9p24.1
Functionis a member of the DnaJ heat shock protein family, which functions as a co-chaperone in the endoplasmic reticulum (ER).
Subcellular LocalizationDNAJB9 is exclusively localized to the ER lumen, where it performs its chaperone functions. Its retention is mediated by
Molecular Weight27 kDa
Amino Acids292 aa
Exons5
UniProt ID[Q9Y3X0](https://www.uniprot.org/uniprot/Q9Y3X0)
Ensembl IDENSG00000102948
GeneCardsDNAJB9
Human Protein AtlasDNAJB9
J domain functionStimulates BiP ATPase activity
Substrate bindingDelivers folded/unfolding proteins to BiP
Allosteric regulationModulates BiP substrate affinity
Associated DiseasesALS, Aging
InteractionsProteins, IL1A, HSPA1A
KG Connections30 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

DNAJB9 Gene

gene · 2073 words

ER Stress in Corticobasal Syndrome

mechanism · 3015 words

Hsp70/Hsp90 Chaperone Pathway in Parkinson's Disease

mechanism · 2373 words

DNAJB9 Protein

protein · 1629 words

FGF1 Gene

gene · 672 words

Fibroblast Growth Factor 5

gene · 566 words

Pathway Diagram

graph TD
    DNAJB9["<b>DNAJB9</b>"]
    Aging{"Aging"}
    DNAJB9 -->|"associated with"| Aging
    Als{"Als"}
    DNAJB9 -->|"associated with"| Als
    Ms{"Ms"}
    DNAJB9 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    DNAJB9 -->|"interacts with"| Carcinoma
    ALS{"ALS"}
    DNAJB9 -->|"associated with"| ALS
    Nf__b(["Nf-Kappab"])
    DNAJB9 -->|"associated with"| Nf__b
    HSPA1A["HSPA1A"]
    DNAJB9 -->|"associated with"| HSPA1A
    FN1["FN1"]
    DNAJB9 -->|"protects against"| FN1
    ERN1["ERN1"]
    DNAJB9 -->|"protects against"| ERN1
    PDIA6["PDIA6"]
    DNAJB9 -->|"protects against"| PDIA6
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    DNAJB9 -->|"interacts with"| Unfolded_Protein_Response
    AGING["AGING"]
    DNAJB9 -->|"associated with"| AGING
    HSPA1A -->|"associated with"| DNAJB9
    PECAM1["PECAM1"]
    PECAM1 -->|"protects against"| DNAJB9
    FOS["FOS"]
    FOS -->|"protects against"| DNAJB9
    FGF1["FGF1"]
    FGF1 -->|"protects against"| DNAJB9
    FGF5["FGF5"]
    FGF5 -->|"protects against"| DNAJB9
    IL1A["IL1A"]
    IL1A -->|"interacts with"| DNAJB9
    XBP1["XBP1"]
    XBP1 -->|"protects against"| DNAJB9
    AND["AND"]
    AND -->|"associated with"| DNAJB9
    AGING -->|"associated with"| DNAJB9
    style DNAJB9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
Age-Related Diseasesbiomarker_fordisease0.85
Agingassociated_withdisease0.65
Alsassociated_withdisease0.65
Msinteracts_withdisease0.65
Carcinomainteracts_withdisease0.65

Incoming (11)

SourceRelationTypeStr
HSPA1Aassociated_withgene0.60
PECAM1protects_againstgene0.60
FOSprotects_againstgene0.60
FGF1protects_againstgene0.60
FGF5protects_againstgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found