Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABA-A receptor beta3 subunit - critical inhibitory receptor in neurological disease
| Gene Symbol | GABRB3 |
| Aliases | GABA-A receptor beta3 subunit |
| Chromosome | 15q12 |
| Protein Type | Receptor |
| Function | is a critical component of many GABA-A receptor subtypes, including the predominant benzodiazepine-sensitive receptors in the thalamus and cortex. |
| Primary Expression | Brain (thalamus, cortex, hippocampus), widespread CNS |
| Molecular Weight | 54 kDa |
| Amino Acids | 473 aa |
| UniProt ID | P28472 |
| OMIM | 137192 |
| GeneCards | GABRB3 |
| Human Protein Atlas | GABRB3 |
| Genomic Coordinates | chr15:26,700,000-27,100,000 (GRCh38) |
| Gene Length | ~250 kb |
| Number of Exons | 10 coding exons |
| Associated Diseases | neurodegeneration |
| Interactions | MAPT, PSEN1, SCARB2, TFAM, TREM2, UCHL1 |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["GABRB3"]
N1["A2M"]
N1 -->|"interacts with"| N0
N2["BCHE"]
N2 -->|"interacts with"| N0
N3["CHRFAM7A"]
N3 -->|"interacts with"| N0
N4["CNTN1"]
N4 -->|"interacts with"| N0
N5["ESR1"]
N5 -->|"interacts with"| N0
N6["DNA"]
N6 -->|"interacts with"| N0
N7["GABRB2"]
N7 -->|"phosphorylates"| N0
N8["MAPT"]
N0 -->|"interacts with"| N8
N9["PSEN1"]
N0 -->|"interacts with"| N9
N10["SCARB2"]
N0 -->|"interacts with"| N10
N11["TFAM"]
N0 -->|"interacts with"| N11
N12["TREM2"]
N0 -->|"interacts with"| N12
N13["UCHL1"]
N0 -->|"interacts with"| N13
N14["NDUFV1"]
N0 -->|"phosphorylates"| N14
N15["neurodegeneration"]
N0 -->|"implicated in"| N15
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class N0 gene
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class N14 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||