gene

GABRB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
7Outgoing
7Incoming

Summary

GABA-A receptor beta3 subunit - critical inhibitory receptor in neurological disease

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🧬 Gene Info
Gene SymbolGABRB3
AliasesGABA-A receptor beta3 subunit
Chromosome15q12
Protein TypeReceptor
Functionis a critical component of many GABA-A receptor subtypes, including the predominant benzodiazepine-sensitive receptors in the thalamus and cortex.
Primary ExpressionBrain (thalamus, cortex, hippocampus), widespread CNS
Molecular Weight54 kDa
Amino Acids473 aa
UniProt IDP28472
OMIM137192
GeneCardsGABRB3
Human Protein AtlasGABRB3
Genomic Coordinateschr15:26,700,000-27,100,000 (GRCh38)
Gene Length~250 kb
Number of Exons10 coding exons
Associated Diseasesneurodegeneration
InteractionsMAPT, PSEN1, SCARB2, TFAM, TREM2, UCHL1
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: GABRB3 — AlphaFold P28472 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GABRB3

gene · 1004 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

HNRNPH2 Gene

gene · 2633 words

GABRA5 Gene

gene · 2239 words

GABRB3 Gene

gene · 1921 words

Gabaa Receptor Neurons

cell_type · 1860 words

Pathway Diagram

flowchart TD
    N0["GABRB3"]
    N1["A2M"]
    N1 -->|"interacts with"| N0
    N2["BCHE"]
    N2 -->|"interacts with"| N0
    N3["CHRFAM7A"]
    N3 -->|"interacts with"| N0
    N4["CNTN1"]
    N4 -->|"interacts with"| N0
    N5["ESR1"]
    N5 -->|"interacts with"| N0
    N6["DNA"]
    N6 -->|"interacts with"| N0
    N7["GABRB2"]
    N7 -->|"phosphorylates"| N0
    N8["MAPT"]
    N0 -->|"interacts with"| N8
    N9["PSEN1"]
    N0 -->|"interacts with"| N9
    N10["SCARB2"]
    N0 -->|"interacts with"| N10
    N11["TFAM"]
    N0 -->|"interacts with"| N11
    N12["TREM2"]
    N0 -->|"interacts with"| N12
    N13["UCHL1"]
    N0 -->|"interacts with"| N13
    N14["NDUFV1"]
    N0 -->|"phosphorylates"| N14
    N15["neurodegeneration"]
    N0 -->|"implicated in"| N15

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    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 gene
    class N12 gene
    class N13 gene
    class N14 gene

Outgoing (7)

TargetRelationTypeStr
MAPTinteracts_withgene0.60
PSEN1interacts_withgene0.60
SCARB2interacts_withgene0.60
TFAMinteracts_withgene0.60
TREM2interacts_withgene0.60

Incoming (7)

SourceRelationTypeStr
A2Minteracts_withgene0.60
BCHEinteracts_withgene0.60
CHRFAM7Ainteracts_withgene0.60
CNTN1interacts_withgene0.60
ESR1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found