gene

BCHE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCHE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

BCHE is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, therapeutic target. Associated with Alzheimer, Anxiety, Dementia. Connected to 73 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BCHE
Aliases	Page for BCHE Gene
Chromosome	3q26.1
Protein Type	Hydrolase
Function	Unlike acetylcholinesterase (AChE), which is primarily localized at neuronal synapses, BuChE is found in: - Plasma — the major source of circulating BuChE - Liver — primary site of synthesis - Brain —
Primary Expression	Liver, Brain (cerebral cortex, hippocampus, basal forebrain), Serum
Subcellular Localization	neuronal synapses, BuChE is found in:
Amino Acids	574 aa
Exons	4
Pathways	autophagy pathway
UniProt ID	P06276
NCBI Gene ID	163
Ensembl ID	ENSG00000114200
OMIM	177400
GeneCards	BCHE
Human Protein Atlas	BCHE
Associated Diseases	Alzheimer, Alzheimer'S Disease, Anxiety, Dementia, Depression
Known Drugs/Compounds	antidementia drugs
Interactions	BACE1, CHRFAM7A, CNTN1, ESR1, GABRB3, MAPT
KG Connections	156 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BCHE — AlphaFold P06276 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BCHE["BCHE"] -->|"associated"| Alzheimer["Alzheimer"]
    BCHE["BCHE"] -->|"therapeutic target"| Dementia["Dementia"]
    BCHE["BCHE"] -->|"associated"| Depression["Depression"]
    BCHE["BCHE"] -->|"associated"| Anxiety["Anxiety"]
    BCHE["BCHE"] -->|"associated"| Dementia_1["Dementia"]
    BCHE["BCHE"] -->|"interacts"| Alzheimer_2["Alzheimer"]
    MAOB["MAOB"] -->|"associated"| BCHE["BCHE"]
    GABRA1["GABRA1"] -->|"associated"| BCHE["BCHE"]
    CHAT["CHAT"] -->|"associated"| BCHE["BCHE"]
    CYP2D6["CYP2D6"] -->|"associated"| BCHE["BCHE"]
    style BCHE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (105)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
antidementia drugs	modulates	drug	0.75
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Schizophrenia	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Vascular Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	inhibits	disease	0.65
ALS	transports	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Cancer	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Dystonia	inhibits	disease	0.65
Schizophrenia	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
COMT	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
BACE1	interacts_with	gene	0.60
CHRNA7	transports	gene	0.60
CYP2D6	transports	gene	0.60
SLC22A1	transports	gene	0.60
CYP3A4	transports	gene	0.60

Incoming (51)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
IL6	interacts_with	gene	0.60
APOE4	interacts_with	gene	0.60
SLC6A3	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
ABCG2	associated_with	entity	0.60
SLC6A4	associated_with	gene	0.60
PPAR	transports	gene	0.60
APOE	inhibits	gene	0.60
ABCB1	transports	gene	0.60
CHAT	transports	gene	0.60
ACE	transports	gene	0.60
SLC6A2	associated_with	gene	0.60
A2M	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
CYP3A5	associated_with	gene	0.60
ACHE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
DEMENTIA	inhibits	gene	0.60
GENES	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
POR	transports	gene	0.60
PARKINSON	inhibits	gene	0.60
PER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BCHE

Understanding Entity Pages

Summary

Wiki Pages (21)

BCHE Gene - Butyrylcholinesterase

blarcamesine-axon

Cholinergic System Dysfunction in Neurodegeneration

Section 216: Advanced Pharmacogenomics and Precision Therapeutics for CBS/PSP

acetylcholine-signaling-neurodegeneration

GABRB3 Gene

Cholinesterase Inhibitors - Comprehensive Guide

Horizontal Limb of the Diagonal Band (HDB)

Cholinergic Signaling Pathway in Neurodegeneration

acetylcholinesterase-neurons

Precision Medicine in Neurodegeneration

NBEA — Neurobeachin

Ferulic Acid Carbamate Derivatives for Alzheimer's Disease

Butyrylcholinesterase (BuChE) Protein

DLB Treatment Response Biomarkers — Predicting Cholinesterase Inhibitor Response

GABRB3

slc30a8

HTR2C Gene

Vesicular Acetylcholine Transporter Neurons